Exercise Timing and Postprandial Glucose Responses
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorTechnical University of Munich
About this trial
This interventional crossover study examines the effect of exercise timing relative to meal intake on postprandial glucose responses in healthy, physically active young adults. Participants complete five experimental conditions involving endurance exercise performed before or after breakfast or dinner, as well as a non-exercise control condition, while wearing a continuous glucose monitoring device.
Postprandial glucose responses are assessed for the three consecutive meals following each exercise session. Following morning exercise, outcomes are assessed after breakfast, lunch, and dinner on the same day. Following evening exercise, outcomes are assessed after dinner on the same day and after breakfast and lunch on the subsequent day. All meals are standardized and consumed at fixed clock times.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18 to 35 years
Body mass index 18.5 to 24.9 kg per square meter
Able to complete 45 minutes of continuous running at an intensity corresponding to 75 to 85 percent of maximal heart rate without stopping
Engages in regular endurance-type physical activity
Disqualifiers
Acute or chronic illness
Metabolic disorders or conditions associated with altered glucose or lipid metabolism
Use of medications known to interfere with glucose metabolism or study outcomes
Intolerance or allergy to components of the standardized study diets
Trial design
Design model
Crossover
Treatments tested in this trial
Timed Endurance Exercise
BehavioralThe exercise intervention consists of a 45 minute continuous outdoor run performed on a standardized route. Participants are instructed to maintain a consistent running pace across all exercise conditions. Exercise intensity is standardized using a target heart rate corresponding to 75 to 85 percent of maximal heart rate, and participants must be able to complete 45 minutes of continuous running at this intensity without stopping. Heart rate, duration, distance, and pace are recorded using a heart rate monitor and GPS enabled device. Ambient temperature and precipitation are recorded for each session. Exercise sessions may be rescheduled in cases of extreme weather or acute illness.
No Exercise Control
BehavioralThis intervention involves a non-exercise control condition
Treatment groups
30 Participants
are divided into 5 treatment groupsGroup A: Run Before BreakfastExperimental treatment 1 intervention
Group B: Run After BreakfastExperimental treatment 1 intervention
Group C: Run Before DinnerExperimental treatment 1 intervention
Group D: Run After DinnerExperimental treatment 1 intervention
Group E: No Exercise ControlExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
3-hour postprandial glucose area under the curve (AUC)
The area under the curve for interstitial glucose concentration during the 3-hour period following each of the three consecutive meals assessed after each exercise or control condition, measured using continuous glucose monitoring.
Time frame
During each intervention condition within the 14-day study period, assessed over the 3-hour period following each of the three consecutive meals after each conditionSecondary outcomes
1
Incremental postprandial glucose AUC
Incremental area under the curve for interstitial glucose concentration during the 3-hour postprandial period following each assessed meal, calculated relative to pre-meal baseline glucose concentration.
Time frame
During each intervention condition within the 14-day study period, assessed over the 3-hour period following each of the three consecutive meals after each condition2
Peak postprandial glucose concentration
Maximum interstitial glucose concentration following each meal.
Time frame
During each intervention condition within the 14-day study period, assessed over the 3-hour period following each of the three consecutive meals after each condition3
Time to peak glucose
Time from meal initiation to peak interstitial glucose concentration.
Time frame
During each intervention condition within the 14-day study period, assessed over the 3-hour period following each of the three consecutive meals after each condition4
Subjective appetite ratings
Subjective sensations of hunger, fullness, prospective food consumption, desire to eat, nausea, and thirst are assessed using electronic 100-mm visual analog scales administered before and after each meal and each exercise session.
Time frame
Repeatedly during each intervention condition within the 14-day study period, assessed before and after each meal and exercise sessionSponsors and contacts
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Source ClinicalTrials.gov