Exercise to Improve Sleep in Parkinson's Disease

ConditionParkinson Disease

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age40+

SponsorMcGill University

About this trial

This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with Parkinson's disease (PD). Furthermore, the project will investigate whether the potential positive exercise-induced changes in sleep are associated with improvements in different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT), resistance training (RT), multimodal training (MT), or will be allocated to a control condition (i.e., waiting list - CON) for 12 weeks. Training will be performed three times/week. The assessments will be conducted at baseline, post-intervention, and follow-up (i.e. 8 weeks after the intervention) by assessors blinded to the participants' group allocation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn & Yahr Scale stages 0.5-3.5);

On a stable dosage of medication during the previous month;

Having poor sleep quality defined as a score > 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality;

Disqualifiers

Having atypical parkinsonism, dementia, stroke, or any other neurological condition;

Presenting severe untreated obstructive sleep apnea (OSA);

Having a Montreal Cognitive Assessment (MoCA) score <18

Having a Beck Depression Inventory score >31;

Trial design

Design model

Parallel

Treatments tested in this trial

Cardiovascular training (CT)
Behavioral
12 weeks of CT
Resistance training (RT)
Behavioral
12 weeks of RT
Multimodal training (MT)
Behavioral
12 weeks of MT

Treatment groups

150 Participants

are divided into 4 treatment groups

Group A: Cardiovascular training (CT)Experimental treatment 1 intervention

Group B: Resistance training (RT)Experimental treatment 1 intervention

Group C: Multimodal training (MT)Experimental treatment 1 intervention

Group D: Control condition (CON; waiting list)No intervention 0 interventions

Trial outcomes

Primary outcomes

Changes in objective sleep quality

Sleep efficiency (SE) measured with polysomnography; SE (%) = Time asleep while in bed \* 100; values = 0-100%; higher values reflect better SE.

Time frame