Exercise Training and Fat Metabolism in Postmenopausal Women
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age50-75
SponsorFlorida State University
About this trial
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Women
Postmenopausal (50-75 yrs.)
Obese (BMI 30-50 kg/m2)
Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
Disqualifiers
Engaging in purposeful resistance training or endurance training (> 20min/day, > 2 days/week)
Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
Type 1 or type 2 diabetes
Medical problems in which exercise is contraindicated, such as chronic infections
Trial design
Design model
Parallel
Treatments tested in this trial
Resistance Exercise
Behavioral200 Kcal worth of weightlifting, 3 times/week for 12 weeks
Endurance Exercise
Behavioral200 Kcal worth of treadmill walking, 3 times/week for 12 weeks
Treatment groups
120 Participants
are divided into 2 treatment groupsGroup A: Resistance ExerciseExperimental treatment 1 intervention
Group B: Endurance ExerciseExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks
Changes in physical activity (walking)-stimulated lipolysis will be assessed as measured by glycerol concentration in dialysate samples from subcutaneous abdominal adipose tissue utilizing a powerful in-vivo microdialysis methodology
Time frame
12 weeks of resistance or endurance training2
Change from baseline gluteal adipose tissue glycerol concentration at 12 weeks
Changes in physical activity (walking)-stimulated lipolysis will be assessed as measured by glycerol concentration in dialysate samples from gluteal adipose tissue utilizing a powerful in-vivo microdialysis methodology
Time frame
12 weeks of resistance or endurance training3
Change from baseline whole-body lipolysis at 12 weeks
Whole body lipolysis will be measured using whole body rate of appearance of 2H5-glycerol in blood samples collected at rest, during walking exercise, and for 120 minutes after exercise.
Time frame
12 weeks of resistance or endurance trainingSecondary outcomes
1
Change in blood flow as measured by ethanol concentrations in dialysate samples from subcutaneous abdominal adipose tissue
Ethanol (\~10 mM) will be included with the perfusion medium through the microdialysis probe. Blood flow will be expressed as a ratio of the ethanol concentration in the dialysate (outflow) and the ethanol concentration in the perfusate (inflow)
Time frame
12 weeks of resistance or endurance training2
Change in dialysate ethanol data in subcutaneous gluteal adipose tissue
Ethanol (\~10 mM) will be included with the perfusion medium through the microdialysis probe. Blood flow will be expressed as a ratio of the ethanol concentration in the dialysate (outflow) and the ethanol concentration in the perfusate (inflow)
Time frame
12 weeks of resistance or endurance training3
Change in the ratio of 13CO2 to 12CO2 in breath samples
This measure will allow for the calculation of whole-body fat oxidation under conditions of rest, walking exercise, and hyperinsulinemiceuglycemic clamp.
Time frame
12 weeks of resistance or endurance training4
change in body composition
Body composition (body mass, lean mass, fat mass, visceral fat) will be measured before and after 12 weeks of resistance or endurance training.
Time frame
12 weeks of resistance or endurance trainingSponsors and contacts
Click on the lead sponsor to view all of their trials.
Florida State University
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Pennington Biomedical Research Center
Collaborator
University of Arkansas
Collaborator
Source ClinicalTrials.gov