Exploration of Mechanisms for Weaning Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe First Affiliated Hospital of Guangzhou Medical University
About this trial
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).
The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Invasive mechanical ventilation for at least 48 hours
Disqualifiers
neuromuscular disease；Postoperative patients or patients with traumatic brain injury
Trial population
Patients undergoing weaning from mechanical ventilation；Hemodynamic stability
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Monitoring of respiratory mechanics parameters
Diagnostic testPhysiologic recording instrumentation measure maximal transdiaphragmatic pressure，twitch diaphragmatic pressure and maximal diaphragmatic electromyography
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: weaning success1 intervention
Group B: weaning failure1 intervention
Trial outcomes
Primary outcomes
1
weaning success
passed SBT trial and weaning from mechanical ventilation success with no need of reintubation
Time frame
Day 2Sponsors and contacts
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Source ClinicalTrials.gov