Exploring Biomarkers in the Heat and Moisture Exchange Filters
ConditionRespiratory Inflammation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAalborg University Hospital
About this trial
When patients undergo major surgery, they are connected to a ventilator during anesthesia. A heat and moisture exchange filter (HME filter) is routinely placed in the ventilator tubing to ensure that the inhaled air is warm and humidified. Today, HME filters are used routinely in all ventilator treatments. They are typically replaced once a day and discarded as regular waste after use.
The purpose of this study is to investigate whether HME filters contain proteins and small biological particles from the patient's exhaled air.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
≥18 years, able to understand study information in Danish.
Admitted for elective surgery for non-malignant conditions with either intravenous or inhalation anaesthesia and invasive mechanical ventilation according to standard practice.
Expected invasive mechanical ventilation > 1 hour.
Possess legal capacity.
Disqualifiers
Patients who are transferred to the ICU for continuous invasive mechanical ventilation after end of elective surgery.
Known chronic lung disease.
Trial population
The investigators will include adult patients who are scheduled for elective surgery for non-malignant conditions under general anesthesia with invasive mechanical ventilation. The written and oral study information will be provided at the standard preoperative consultation with the anesthesiologist the day before elective surgery.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
10 Participants
are grouped into 1 trial groupGroup A: Elective surgery patients with expected mechanical ventialtion > 2 hours
Trial outcomes
Primary outcomes
1
Total endogenous protein amount captured in HME filters measured by standard biochemical assays.
Quantification of the total amount of endogenous proteins recovered from heat moisture exchange (HME) filters using Biuret based analysis.
Time frame
Through study completion, an average of 3 months.Secondary outcomes
1
Protein molecular weight and isoelectric point distribution in proteins captured by HME filters.
Distribution and representation of captured proteins according to molecular weight and isoelectric point characteristics determined by proteomic analysis.
Time frame
Through study completion, an average of 3 months.Other outcomes
1
Between-subject variation in exhaled breath protein concentration measured by proteomic analysis.
Variation in protein concentration across HME filter samples collected from different participants, measured using protein quantification methods.
Time frame
Through study completion, an average of 3 months.Sponsors and contacts
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Source ClinicalTrials.gov