Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.
Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.
Inability to complete daily symptom diaries and/or attend for clinical assessments.
Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment.
Pregnancy.
Patients with chronic lung disease under the care of respiratory teams at Royal Brompton and Harefield (NHS) Hospitals.
Cohort
Prospective
Not listed
Respiratory viruses detection during exaccerbations
The percentage of chronic airway disease exacerbations where a respiratory virus is detected (with sub-classification of the specific viral subtypes).
Differences in symptoms between viral and non-viral exacerbations
Differences in magnitude of deterioration in symptoms (as measured by validated symptom score) between viral and non-viral exacerbations.
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