Exploring Neurophysiological Markers of Brain Health
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age22-100
SponsorThe University of Texas at Dallas
About this trial
The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health.
In this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Must be an active brain imaging participant in The BrainHealth Project (NCT04869111)
Minimum age of 22
Fluent in English
Able to read & hear information over a computer
Disqualifiers
A diagnosis of a neurodegenerative disease
A history of stroke, concussion, or brain injury that currently hinders them from functioning at their prior level
A diagnosis of autism spectrum disorder that currently hinders them from functioning independently.
Metallic brain implants or fragments (like a shunt, pacemaker, clips, coils, bullet fragments, cochlear implants)
Trial design
Design model
Single group
Treatments tested in this trial
Strategic Memory Advanced Reasoning Training teaches meta-cognitive strategies for individuals to apply to their daily lives for improved performance
BehavioralOnline SMART is a curriculum that teaches strategies of how to use the brain better, in such a way that may improve brain health and performance. SMART strives to achieve optimal cognitive function realized by the brain's ability to efficiently manage complex information by abstracting its essential meaning rather than attempting to memorize details, and to prioritize the information in order to attend to the most relevant parts. Stress Solutions extends the SMART principles to relevant domains of stress and resilience.
Treatment groups
63 Participants
are divided into 1 treatment groupGroup A: Online Strategic Memory Advanced Reasoning Training & Stress SolutionsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Correlation of DELPHI-MD Output Measures with the online BrainHealth Index
Evaluate the strength and significance of correlations between DELPHI-MD output metrics (e.g., cortical excitability, local/global mean field potentials, response amplitude, and latency) and scores from the BrainHealth Index. Unit of Measurement: Correlation coefficient (r). (Minimum value: -1.0, Maximum value: 1.0) (Higher value represents stronger correlation)
Time frame
Up to one yearSecondary outcomes
1
Correlation of DELPHI-MD Output Measures with Quantitative fMRI Metrics
Assess the relationships between DELPHI-MD output metrics and the following fMRI metrics collected in separate study (i) functional connectivity, (ii) cerebral blood flow, (iii) cerebrovascular reactivity, and (iv) white matter integrity. Unit of Measurement: Correlation coefficient (r). (Minimum value: -1.0, Maximum value: 1.0) (Higher value represents stronger correlation)
Time frame
Up to one yearSponsors and contacts
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Source ClinicalTrials.gov