Exploring the Acute and Dynamic Relationships Between Movement and Pain in Older Adults With Musculoskeletal Pain

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-85
SponsorIndiana University

About this trial

The purpose of this research study is to evaluate the effect of brief bouts of intermittent walking on bodily pain, pain during movement, and how the body adapts to musculoskeletal pain in older adults.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Community-dwelling men and women

Answer yes to the following question: Have you experienced any musculoskeletal pain (pain affecting joints, bones, ligaments, tendons or muscles) in the past month?

Disqualifiers

Cardiovascular issues such as uncontrolled blood pressure over 150/99 mmHg, heart failure, or history of acute myocardial infarction;

Angina in the last month (squeezing, pressure, heaviness, tightness, or pain in chest)

Serious systemic disease or condition (e.g., severe osteoarthritis, injury) that restricts normal daily activities

Neurological disease (e.g., Parkinson's Disease, multiple sclerosis, epilepsy)

Trial design

Design model

Crossover

Treatments tested in this trial

  • Intermittent light walking

    Behavioral

    The participant will remain seated throughout the 1 hour experimental period. During this 1-hour period, participants will complete six bouts of 2.5-minutes of light intensity walking. Overall, the bouts will occur on six occasions, providing a total of 15 minutes of light intensity activity.

  • uninterrupted sitting

    Behavioral

    The participant will remain seated throughout the experimental period and will be instructed to minimize excessive movement, only rising from the chair to void. This experimental condition is designed to mimic prolonged uninterrupted sedentary behavior.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Uninterrupted Sitting for 1 hourExperimental treatment 1 intervention
Group B: 1 hour of sitting interrupted with 2.5 minute bouts of light intensity walkingExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Mechanical Temporal Summation of Pain (TS)

TS will be administered on the back of the left hand. First, a single pinprick stimulus using a von Frey filament of 6.65 Mn or 300 g will be applied to the body site. Participants will rate the perceived pain intensity using a numeric rating scale of 0 (no pain at all) to 100 (worst pain imaginable). Then, a series of 10 pinprick stimuli (6.65 Mn) will be administered at a rate of 1 Hz, applied to the body site within an area of 1 cm2. The temporal summation value will be calculated as the difference between the first and last stimuli.

Time frame
Pre and post the 1-hour experimental conditions
2

Conditioned Pain Modulation

CPM will be assessed by determining the ability of a cold water bath (conditioning stimulus) to diminish pressure pain thresholds (PPTs) and temporal summation (TS) (test stimuli) applied at a separate body site. For the CPM trials, PPTs and TS will be measured pre and post a conditioning stimulus. Conditioning stimulus: At least 4 minutes will separate the pre pain assessments (i.e., PPT, TS) and the initiation of the conditioning stimulation, during which subjects will sit quietly. Then, participants will immerse their right hand up to the wrist in a cold water bath maintained at 10oC for up to 1 minute or until they report intolerable pain. The dependent variable for the CPM test will be the change in the test stimuli (PPT and TS) following the conditioning stimulus.

Time frame
Pre and post the 1-hour experimental conditions
3

Movement-evoked pain during the 30-second chair stand test

This test will be administered using a folding chair without arms, placed against a wall to prevent it from moving during the test. The test begins with the subject seated in the middle of the chair, feet at an angle slightly back from the knees, with one foot slightly in front of the other to help maintain balance when standing. Arms will be crossed at the wrists and held against the chest. At the signal of "go", subjects will rise to a full stand and then return back to the initial position. The subjects will be encouraged to complete as many full stands as possible within a 30-s time limit. Participants will rate their current bodily pain on a 0 to 10 numeric rating scale (NRS), with 0 indicating "No pain" and 10 indicating "Pain as bad as you can imagine". Participants will rate their bodily pain before, during, and after the chair stand test as a measure of movement evoked pain.

Time frame
Will be administered immediately after the 1-hour experimental conditions.

Secondary outcomes

Other outcomes

1

Physical Activity and Sedentary Behavior Questionnaire (PASB-Q)

The PASB-Q has 7 items to measure reported aerobic PA, muscle strengthening PA, perceived aerobic fitness, and sedentary behavior.

Time frame
At baseline during one of the study sessions
2

The Physical Activity Scale for the Elderly (PASE)

The PASE has a total of 18 items using a 4-point scales and yes/no questions. The items capture seven dimensions of physical activity. People with higher scores are more physically active.

Time frame
At baseline during one of the study sessions
3

Movement evoked pain during the six minute walk test

Subjects will be required to walk as far as possible at their usual pace in 6 minutes around a predetermined indoor walking course on a flat surface. The distance subjects cover will be recorded. Participants will rate their current bodily pain on a 0 to 10 numeric rating scale (NRS), with 0 indicating "No pain" and 10 indicating "Pain as bad as you can imagine". Participants will rate their bodily pain before, during, and after the walk as a measure of movement evoked pain.

Time frame
At baseline during each study session.
4

Graded Chronic Pain Scale (GCPS)

The GCPS will be used to measure pain-related severity and disability across 7-items

Time frame
At baseline during one of the study sessions

Sponsors and contacts

Click on the lead sponsor to view all of their trials.