Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorSichuan Provincial People's Hospital

About this trial

This study looks at memory problems after surgery in people with liver disease. We want to know how often these problems happen and what might cause them. The main question it aims to answer is:

1. Do people with liver disease have more memory problems after stomach surgery than people without liver disease? If yes, how much more often? 2. Are changes in stomach bacteria and body chemicals related to these memory problems?

Who can join:

* Adults getting stomach surgery * Both people with and without liver disease

What participants will do:

* Take memory tests before and after surgery * Give stool (poop) and blood samples before and after surgery

Why this matters:

Memory problems after surgery can make recovery harder. If we find that stomach bacteria or body chemicals are involved, doctors might find new ways to prevent these problems in people with liver disease.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age: 18-80 years

Patients with or without liver cirrhosis scheduled for upper abdominal surgery due to various clinical indications

Ability to comply with the study protocol and provide informed consent

Disqualifiers

Comorbid severe cardiac, pulmonary, or renal diseases

Psychiatric disorders

Inability to communicate clearly

Any condition preventing effective communication or cooperation

Trial population

Hospitalized patients scheduled for surgical treatment at Sichuan Provincial People's Hospital.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

133 Participants
are grouped into 2 trial groups
Group A: Patients with liver cirrhosis scheduled for upper abdominal surgery
Group B: Patients without liver cirrhosis scheduled for upper abdominal surgery

Trial outcomes

Primary outcomes

1

The incidence of postoperative delirium within 7 days after upper abdominal surgery in patients with liver cirrhosis.

Time frame
within 7 days after sugery

Secondary outcomes

1

The incidence of postoperative delirium within 7 days after upper abdominal surgery in patients without liver cirrhosis.

Time frame
within 7 days after sugery

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: