Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU

ConditionsSepsis Septic Shock

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-65

SponsorAssiut University

About this trial

This observational study compares extended versus intermittent beta-lactam infusion in sepsis patients, assessing survival, clinical cure rates, and practical ICU challenges. The findings will guide optimal antibiotic protocols, potentially improving sepsis outcomes through precision dosing strategies.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged: 18 - 65

Temperature: over 38 degree celsius

Heart rate: over 100 beats per minute

Respiratory rate: over 20 breaths per minute

Disqualifiers

Hypersensitivity to Beta-lactams

Pregnancy

Very low probability of survival using APAACHE II score > 34 points.

Immunodeficency or taking immunosuppressive medications

Trial population

Critically ill patient diagnosed with pneumonia at Critical care unit at Assiut University Hospital

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Extended beta-lactam antibiotics
Drug
Group A will be receiving extended infusion of beta-lactam antibiotic over 4 hours.
Intermittent Beta-lactam antibiotics
Drug
Group B will be receiving intermittent infusion of beta-lactam antibiotic over 30 minutes.

Treatment groups

90 Participants

are divided into 2 treatment groups

Group A: Group A1 intervention

Group B: Group B1 intervention

Trial outcomes

Primary outcomes

All-cause mortality at 28 days from the date of randomization.

Time frame

Baseline and 28 days

Secondary outcomes

Clinical cure

defined as completing the full course of beta-lactam therapy within 14 days without requiring additional antibiotics for the same infection within 48 hours after treatment cessation.

Time frame

Baseline and 16 days

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: