The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.
aged over 18
Person who participated in the Stanislas Cohort
Person affiliated to a social security scheme or beneficiary of such a scheme
Person having received complete information on the organization of the research and having signed an informed consent
Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric treatment under Articles L. 3212-1 and L. 3213-1
Pregnant woman, parturient or nursing mother
Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
Person of full age unable to express consent
Single group
Blood and urine samples
Biological/VaccineBlood and urine samples
Blood samples
GeneticBlood samples
Cardiovascular assessment
Other interventionEchocardiography, Lung ultrasound, pulse wave velocity, carotid stiffness and thickness, Central and peripheral blood pressure, carotid pulse pressure, abdominal aorta ultrasound, jugular vein ultrasound, liver elastography (Optional).
Dietary intake
BehavioralFood frequency questionnaires, ''Dutch eating behaviour questionnaire'' and dietary supplement questionnaire
Anthropometric parameters
Other interventionMeasurement of height, weight, abdominal circumference, hip circumference, arm circumference
Hemodynamic parameters
Other interventionSystolic pressure index measurement
Hemodynamic parameters
Other interventionHeart rate measurements, blood pressure measurements, orthostatic BP measurements
Hemodynamic parameters
Other interventionBlood pressure measurements by "unattended BP" monitor over 5 min
Hemodynamic parameters
Other interventionElectrocardiogram
Assessment of compliance with antihypertensive treatments for treated participants
BehavioralEVALOBS scale and compliance questionnaire
Ambulatory 24 hours measurment of blood pressure
Other interventionFor the first 100 patients willing to participate
24 hours urinary collection
Biological/VaccineFor the first 100 patients willing to participate. For biobank constitution and measurement of microalbuminuria, creatininuria, osmolarity, natriuresis, kaliuresis, urea, proteinuria and urine dipstick
General questionnaires
Other interventionCollection of socio-demographic data such as age, level of education, profession, household income, smoking status, physical activity, perception of health, prematurity, height and weight at birth, family and personal history especially cardiovascular (history of stroke, myocardial infarction, heart failure, current pathologies, drugs, tobacco...)
Women specific questionnaire
Other interventionWomen specific questionnaire
Women specific questionnaire
BehavioralWomen specific questionnaire
NYHA dyspnea questionnaire
Diagnostic testDetermination of NYHA class.
Anxiety questionnaire
BehavioralAssessment of anxiety
Epworth Sleepiness Scale
Behavioralsleep quality assessment
A questionnaire on the "perception of the management of cardiovascular risk factors"
Other interventionPatient's evaluation of cardiovascular risk factors by the health system
A questionnaire on eating behaviors
BehavioralAssessment of eating behaviors
A questionnaire on eating habits to determine consumer profiles
BehavioralAssessement of eating habit to create a consumer profile
A questionnaire on food supplements use
Dietary supplementEvaluation od food supplements intake
SARS-CoV-2 Infection Questionnaire
Other interventionSARS-CoV-2 Infection Questionnaire
Instantaneous expired air analysis
Other interventionCarbon monoxyde analysis in expired air
Capillary sampling
Biological/VaccineCapillary sampling for pollutant analysis (Optional)
Indexed left ventricular mass measured by echocardiography
Left ventricular volume measured by echocardiography
Tissue doppler imaging e' wave measured by echocardiography
Ratio E/e' measured by echocardiography
Estimation of the glomerular filtration rate (CKD-EPI formula)
Composite endpoint of degradation of renal function (With outcome 11)
Proteinuria (on sample)
Composite endpoint of degradation of renal function (With outcome 10)
Blood glucose
Composite endpoint of degradation of metabolic parameters (With outcome 13 and 14)
Change in HbA1C
Composite endpoint of degradation of metabolic parameters (With outcome 12 and 14)
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