Fast Cardiac Bone SPECT-CZT in Transthyretin Cardiac Amyloidosis
ConditionCardiac Amyloidosis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-95
SponsorCentral Hospital, Nancy, France
About this trial
Transthyretin cardiac amyloidosis (ATTR-CA) is traditionally diagnosed using planar bone scintigraphy with a Perugini visual score ≥ 2. Fast cardiac CZT-SPECT will be evaluated for its ability to reproduce this classification and provide reproducible quantitative myocardial uptake metrics.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients who were routinely referred for bone scintigraphy for suspected transthyretin cardiac amyloidosis (ATTR-CA) between April 2024 and April 2025.
Disqualifiers
Patients who object to the use of their data
Trial population
Retrospectively enrolled patients routinely referred for bone scintigraphy for suspected transthyretin cardiac amyloidosis (ATTR-CA) . During this period, a rapid three-dimensional CZT-SPECT cardiac acquisition was systematically attempted in addition to conventional planar imaging, depending on camera availability, for diagnostic purposes, particularly for identifying blood-pool activity and other extracardiac confounding uptake areas
Trial design
Design model
Other
Time perspective
Retrospective
Treatments tested in this trial
bone scintigraphy
Other interventionFast CZT camera bone scintigraphy and bone scintigraphy with conventional camera (standard care)
Treatment groups
200 Participants
are divided into 1 treatment groupGroup A: Patients referred for bone scintigraphy for suspected ATTR-CA1 intervention
Trial outcomes
Primary outcomes
1
to evaluate whether fast CZT-SPECT recordings can reproduce the diagnosis of ATTR-CA obtained using Perugini scoring on standard planar images, either by applying Perugini scoring to planar projections or by using quantitative parameters
Comparison between Perugini score obtained on the bone scan scintigraphy performed with CZT SPECT and performed with conventional camera
Time frame
one dayLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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