Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-75
SponsorKarolinska University Hospital
About this trial
Patients undergoing allogenic stem cell transplantation are regularly followed up in the outpatient clinic at Karolinska University Hospital. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Meanwhile liquor samples and advanced PET imaging techniques are available for these patients as part of a research project allowing extensive immunological and radio-morphological studies.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Patients undergone allogeneic stemcell transplantation
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
PET investigation
RadiationTrial subjects will undergo two advanced PET investigations
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: Patients with fatigue and cognitive dysfunction1 intervention
Group B: Patients without fatigue and cognitive dysfunction1 intervention
Trial outcomes
Primary outcomes
1
To investigate the role of inflammation on synaptic density and glial cell activation as the cause of mental fatigue and cognitive dysfunction in survivors after alloSCT.
Analysis of PET imaging (both descriptive and radiokinetical) in combination with biological markers for neuroinflammation.
Time frame
2024-2027Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Karolinska University Hospital
Lead sponsor
Karolinska Institutet
Collaborator
Source ClinicalTrials.gov