Feasibility of Noninvasive Trigeminal Nerve Stimulation During Exercise
ConditionCOPD
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorJohns Hopkins University
About this trial
The purpose of this study is to examine 1) effects of cutaneous electrical trigeminal nerve stimulation (eTNS) on respiratory control in healthy volunteers and 2) explore the potential of this approach to mitigate dyspnea in patients with chronic obstructive lung disease (COPD).
Eligibility criteria
Qualifiers
Adults aged 18-50 years
BMI 18-30 kg/m²
Ability to provide informed consent and complete study procedures in English
Disqualifiers
Current daytime respiratory impairment such as uncontrolled asthma, uncontrolled COPD, pneumonia, or interstitial lung disease
Use of supplemental oxygen
Pregnancy or breastfeeding
Current use of acetazolamide, Sodium-glucose cotransporter-2 (SGLT2) inhibitors, or daily opioids
Trial design
Treatments tested in this trial
- Active Stimulation
- Sham Stimulation
- Fan therapy
Treatment groups
40 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Johns Hopkins University
Lead sponsor
Center for Bioengineering Innovation and Design
Collaborator
Source ClinicalTrials.gov