In France, one in 4500 women is affected by the MayerRokitantskyKüsterHauser (MRKH) syndrome which is characterized by the absence of uterus at birth. Currently, the only solutions for these patients are:
* Gestational surrogacy, prohibited in France * Adoption * Resignation
Uterine transplantation could become a good alternative.
This study is conducted in 10 patients with MRKH type I syndrome, who will be transplanted from a living donor uterus
Being aged between 18 and 38 years old
In stable couple, with a pregnancy project, favorable psychological evaluation
No history of cancer and transfusion
Absence of comorbidity (neurological, nephro-urological pathology, infectious, psychiatric or psychological pathology)
Extreme oligo-astheno-spermia and azoospermia in the husband
History of abdominopelvic surgery excluding uncomplicated appendectomy; vaginal residue not allowing anastomosis
Known thromboembolic risk factor
No Compatibility with the recipient (group, rhesus, HLA)
Single group
Uterine transplantation
Procedure/SurgeryUterine transplantation from living donor
Pregnancy
Obtaining of a pregnancy after uterine transplantation from a living donor
Safety assessment of the donor, the recipient and the fœtus
Monitoring of all the Adverse events
Psychological assessment of the donor and the recipient
Psychological consequences linked to the procedure determined by repeated interviews with psychologists
Graft Rejection assessment
Donor-specific antobodies monitoring
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