Observational prospective study evaluating the developement of chronic pancreatitis based on imaging modalities as well as biochemical markers of inflammation, fibrosis and oxidative stress.
Patients with CP (N=50) of any aetiology except gallstone induced CP: CP will be diagnosed based on MANNHEIM criteria .
Cohort 2: Patients with their first attack of AP of any aetiology except gallstone induced AP (N=50). The revised Atlanta criteria for acute pancreatitis will be used as diagnostic criteria.
Cohort 3: Patients with RAP (N=50) except gallstone induced RAP. RAP is defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria.
None
Patients with CP, AC pr RAP who are not: 1. Pregnant or lactating patients 2. Contraindications to magnetic resonance imaging (MRI) or endoscopic ultrasound 3. Known chronic liver disease, chronic renal failure, malignancy, chronic inflammatory bowel syndrome, chronic obstructive lung disease, pulmonary fibrosis. 4. Treatment with anti-inflammatory drugs of any kind at the time of inclusion.
Cohort
Prospective
Diagnostic imaging
Diagnostic testMRI assessments including magnetic resonance cholangiopancreatography (MRCP) and diffusion weighted imaging (DWI) combined with gold standard EUS
Fibrosis progression on endoscopic ultrasound (EUS) or magnetic resonance imaging (MRI)
Progression of fibrosis in the pancreas based on either EUS or MRI
Lean body mass assessed using bioimpedance
Body composition focusing on lean body mass will be assessed using bioimpedance
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