FIND Stroke Recovery - A Longitudinal Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorGöteborg University
About this trial
Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. Some will recover fully after stroke and others will have permanent impairments. Few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. Also, the whole range of mechanisms leading to recovery are not precisely known (1). To monitor those mechanisms one can utilize biomarkers.
In parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). Hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. Biomarkers can later be used for outcome predictions after stroke.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
pre-stroke mRS score of ≥3;
severe neurodegenerative disease, cerebral neoplasm or terminal illness; and
patients considered unlikely to be able to participate in or to understand and/or comply with study procedures during follow-up visits at the hospital.
Trial population
Investigators enrol patients presenting with first-ever ischemic stroke or intracerebral haemorrhage admitted to the stroke units at the Sahlgrenska University Hospital in Gothenburg, Sweden.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Observational - all
Other interventionAll stroke patients are included.
Treatment groups
600 Participants
are divided into 1 treatment groupGroup A: Observational - all1 intervention
Trial outcomes
Primary outcomes
1
Medical data Clinical data
Stroke subtype, medical history, life style questions between baseline and follow-ups
Time frame
Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.2
Stroke severity
Change of National Institutes of Health Stroke Scale (NIHSS) between baseline and follow-ups.
Time frame
Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.3
Functional independence
Change of modified Ranking Scale (mRS) functional independence
Time frame
Pre-stroke estimation, baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.4
Walking ability
Change in functional Ambulation Category between baseline and follow ups.
Time frame
Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.Sponsors and contacts
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Source ClinicalTrials.gov