FIT Exercise in 30d of ULLS-induced Muscle Disuse
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-45
SponsorLance Bollinger
About this trial
This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical de-conditioning including loss of voluntary muscle strength, aerobic capacity, and balance regulation.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Regularly engaging in aerobic exercise (> 150min/wk) and resistance exercise (>1 time per week) for the past 12 months
Education greater than or equal to bachelor's degree (any field)
Disqualifiers
Waist circumference < 55cm or > 90cm (F) and < 75cm or > 100cm (M)
Body mass index < 18.5 or > 29.9
Shoe size < 25 or >29cm.
Not regularly engaging in exercise for previous 12 months
Trial design
Design model
Parallel
Treatments tested in this trial
velocity-based FIT (VBFIT)
Other interventionParticipants will ambulate unilaterally using a shoe modified with a 5cm rocker-style stack and forearm crutches for the duration of the study. All participants will complete two testing sessions prior to ULLS, one testing session at day 13, and two testing sessions at the end of the study. Those assigned to the exercise group will perform a both high-intensity resistance and aerobic exercise three times per week
No Exercise
Other interventionParticipants will ambulate unilaterally using a shoe modified with a 5cm rocker-style stack and forearm crutches for the duration of the study. All participants will complete two testing sessions prior to ULLS, one testing session at day 13, and two testing sessions at the end of the study.
Treatment groups
16 Participants
are divided into 2 treatment groupsGroup A: No ExerciseActive comparator 1 intervention
Group B: velocity-based FIT (VBFIT)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Voluntary activation
Voluntary activation of the quadriceps will be assessed with electrical stimulation of the femoral nerve before, during, and after a maximal voluntary isometric contraction (MVIC) using the interpolated twitch technique.
Time frame
Baseline, day 13, and day 302
Twitch Properties-Electromechanical Delay
Electromechanical delay will be calculated as the time difference between the onset of electrical impulse and onset of torque development during femoral nerve stimulation. This will be measured before and after a maximal voluntary isometric contraction.
Time frame
Baseline, day 13, and day 303
Twitch Properties-Rate of Torque Development
Rate of Torque Development will be calculated as the change in torque divided by the change in time in the linear phase between 20 and 80% of peak twitch torque during femoral nerve stimulation. This will be measured before and after a maximal voluntary isometric contraction.
Time frame
Baseline, day 13, and day 304
Twitch Properties-Time to peak Tension
Time to peak tension will be calculated as the time difference between the onset of electrical impulse and peak twitch torque during femoral nerve stimulation. This will be measured before and after a maximal voluntary isometric contraction.
Time frame
Baseline, day 13, and day 30Secondary outcomes
1
Aerobic Capacity
Subjects will complete a VO2max exercise test on a stationary bicycle. Gas exchange and heart rate data will be collected continuously. Initial workload will be set at approximately 2 METS. Every three minutes, we will add more resistance to the pedals (\~1.5 METS). Subjects will continue to pedal until they can either not maintain pedal speed (50RPM) or until a plateau in VO2 occurs. Pedal force for each limb will be assessed.
Time frame
Baseline and day 302
Ventilatory Threshold
Gas exchange data from the aerobic capacity test (VO2, ventilation; VE, and VCO2) will be used to calculate ventilatory threshold during exercise
Time frame
Baseline and day 303
Substrate utilization
Gas exchange data from the aerobic capacity test (VO2, respiratory exchange ratio; RER, and VCO2) will be used to calculate substrate utilization (energy expenditure, carbohydrate use, and fatty acid oxidation) at varying exercise intensities
Time frame
Baseline and day 304
Body Composition
Bioelectrical Impedance Analysis (BIA) will be used to assess body composition. Subjects will lie supine and have small adhesive electrodes placed on the right hand, wrist, ankle, and foot. A small (imperceptible) electrical current will be delivered to one electrode and the amount of resistance to the electrical current will be used to measure body composition. Percent body fat will be measured. Muscle mass will be calculated using previously established formulae.
Time frame
Baseline and day 30Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Lance Bollinger
Lead sponsor
University of Kentucky
Sponsor institution
University of Louisville
Collaborator
National Aeronautics and Space Administration (NASA)
Collaborator
Source ClinicalTrials.gov