Fluid Balance in Acute Kidney Injury in Critically Ill Patients

ConditionsFluid Balance Acute Kidney Injury Critically Ill Acute Kidney Injury Critically Ill

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorAssiut University

About this trial

This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults. Patients without AKI at entry will have fluids tracked hourly via charts, weights, and labs to assess AKI risk by KDIGO criteria within 7 days. Findings may guide better fluid management to lower AKI rates.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 18 years or older admitted to the ICU.

Patients with no AKI at ICU admission.

AKI secondary to (prerenal cause-renal and post renal with manifestation of hypovolemia)-postoperative settings-On top of CKD up to Stage 111b-Compansated heart failure with indication of fluid therapy

Disqualifiers

Patients with pre-existing end-stage renal disease requiring dialysis.

Patients with known chronic kidney disease stage 4 or higher.

ICU readmissions during the same hospitalization.

Patients who received renal replacement therapy before ICU admission

Trial population

Adult patients aged 18 years or older admitted to the intensive care unit (ICU) at Assiut University Hospital without acute kidney injury (AKI) at admission. Eligible cases include prerenal, renal, postrenal AKI with hypovolemia; postoperative; CKD up to stage IIIb; compensated heart failure needing fluids.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

Incidence of Acute Kidney Injury (AKI)

Development of AKI defined by KDIGO criteria (increase in serum creatinine by ≥0.3 mg/dL within 48 hours or ≥1.5 times baseline within 7 days, or urine output \<0.5 mL/kg/h for 6 hours).

Time frame

Within 7 days after ICU admission

Secondary outcomes

AKI Stage by KDIGO Criteria

Worst stage of AKI (Stage 1: SCr 1.5-2.9x baseline or UO \<0.5 mL/kg/h ≥6h; Stage 2: SCr 3-5.9x or UO \<0.5 mL/kg/h ≥12h; Stage 3: SCr ≥6x or ≥4.0 mg/dL or RIFLE F/ESRD, UO \<0.3 mL/kg/h ≥24h or anuria ≥12h).

Time frame

Within 7 days after ICU admission

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: