Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Age 8-35 years
Clinical diagnosis of keratoconus and seeking CXL treatment
English speaking ability sufficient to comprehend consent with parental assistance
MRI compatible
Claustrophobic
Weight > 285 lbs (weight limit of the MRI table)
Magnetic implants or metal-containing tattoos on their chest or above
Pregnancy
The population under study are patients with keratoconus who are undergoing a corneal cross-linking (CXL) procedure. Keratoconus is an eye condition where the cornea progressively develops abnormally into a cone shape, which can lead to distorted vision and irreversible vision loss The CXL procedure is designed to restore and maintain the shape of the cornea to avoid these complications.
Cohort
Prospective
Not listed
Neural activity related to pain.
Pain-related brain activation measured with fMRI.
Corneal nerve morphology.
Afferent nerve fiber morphology measured with IVCM.
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