Food Genetics Behavior Study
ConditionObesity, Childhood
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age5-7
SponsorUniversity of Pennsylvania
About this trial
A genetic risk for obesity does not always translate to the development of obesity among children, which points to the presence of risk-modifying factors that likely relate to energy balance behaviors as key behavioral drivers. Using an integrated approach to comprehensively examine the interplay between genotype and phenotype, this study will systematically assess the extent to which energy balance behaviors, alone or in combination, in conjunction with family-level influences can modify behavioral and genetic predispositions to childhood obesity in a high-risk sample of predominantly minority children from low-resource backgrounds. Identifying protective factors that may mitigate the impact of obesity risk on weight and adiposity outcomes is critical for moving the prevention of childhood obesity into a new direction.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy children
Children ages 5-7 years
Children with BMI equal to or greater 5th percentile
Mother must be children's biological mother and primary caregiver
Disqualifiers
Children with serious medical conditions or medication use known to affect food intake, body weight, physical activity, or sleep
Children with developmental and/or psychiatric conditions that may impact study compliance
Children with food allergies related to study foods or lactose intolerance
Children with low preference for study foods
Trial design
Design model
Single group
Treatments tested in this trial
Heightened Drive to Eat
BehavioralParticipants' eating rate and eating in the absence of hunger will be assessed during a videotaped experimental meal. The relative reinforcing value of food will be assessed using a computerized behavioral choice task.
Treatment groups
242 Participants
are divided into 1 treatment groupGroup A: Heightened Drive to EatExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Body Mass Index (BMI)
BMI z-score
Time frame
Change from baseline to 1-year follow-up2
Waist circumference
Abdominal waist circumference (cm)
Time frame
Change from baseline to 1-year follow-up3
Body fat
Body fat percentage
Time frame
Change from baseline to 1-year follow-upSponsors and contacts
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Source ClinicalTrials.gov