Frailty and Outcomes in Critically Ill Patients Receiving CRRT
ConditionAcute Kidney Injury
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKarolinska Institutet
About this trial
This nationwide observational cohort study will investigate the association between frailty, chronological age, and clinical outcomes in critically ill patients receiving continuous renal replacement therapy (CRRT) in Sweden. Using data from the Swedish Intensive Care Registry, the study will assess whether the Clinical Frailty Scale (CFS) and other measures of comorbidity and illness severity provide prognostic information beyond chronological age. Outcomes will include 30-day mortality, intensive care unit length of stay, and mortality at 60, 90, and 365 days following intensive care unit (ICU) admission. The study aims to contribute to more individualized assessment of critically ill patients who may require CRRT.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients aged 18 years or older.
Patients treated in an intensive care unit in Sweden.
Patients receiving continuous renal replacement therapy (CRRT) during the ICU stay.
ICU admissions occurring between January 1, 2012, and December 31, 2026, subject to confirmation of the final study period.
Disqualifiers
Age below 18 years.
No treatment with CRRT during the ICU stay. Concealed or temporary personal identity number. Invalid registration date of death. Emigration within 30 days after ICU admission. Missing SAPS3 score.
Trial population
Adult patients (aged ≥18 years) admitted to Swedish intensive care units and receiving continuous renal replacement therapy (CRRT) during their ICU stay between January 1, 2012, and August 15, 2024. Patients will be identified through the Swedish Intensive Care Registry (SIR). The study focuses on the association between age, frailty, illness severity, and clinical outcomes, including mortality and ICU length of stay. Clinical Frailty Scale data will be used when available, with mortality follow-up for up to 365 days after ICU admission.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
22,000 Participants
are grouped into 1 trial groupGroup A: Critically ill patients with AKI and need for CRRT
Trial outcomes
Primary outcomes
1
30-day mortality
All-cause mortality assessed following ICU admission using mortality data available through the Swedish Intensive Care Registry and registry linkage.
Time frame
Within 30 days after ICU admission.Secondary outcomes
1
Intensive care unit length of stay
Duration of ICU stay, assessed using registry data.
Time frame
During the index ICU admission.2
60-day mortality
60-day all-cause mortality following ICU admission.
Time frame
Within 60 days after ICU admission.3
90-day mortality
All-cause mortality following ICU admission.
Time frame
Within 90 days after ICU admission.4
365-day mortality
All-cause mortality following ICU admission
Time frame
Within 365 days after ICU admission.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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