Frequency of Interrupting Sitting and Cognitive Function
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorMaastricht University Medical Center
About this trial
Rationale: Sedentary behavior (SB) has been associated with impaired cognitive function in elderly, and negatively impacts glucose metabolism. Interrupting sitting with physical activity (PA) bouts may exert beneficial effects on cognitive function via an improved glucose metabolism. Nevertheless, the impact of breaking up prolonged sitting with various frequencies of PA bouts remains unexplored in young sedentary adults. Moreover, we hypothesize that the pattern of the breaks modifies the effects. Thus, randomized controlled trials (RCTs) are highly needed to investigate the effects of interrupting sitting with different frequencies of PA on cognitive function and glucose metabolism. We now hypothesize that interrupting sitting with different frequencies of walking breaks differentially affects cognitive function and glucose metabolism.
Objective: The aim is to investigate the effects of breaking up sitting with different frequencies of PA bouts on cognitive function and glucose metabolism in young sedentary adults.
Study design: A randomised, controlled cross-over study will be performed, consisting of four interventions in a counterbalanced order: uninterrupted prolonged sitting, short breaks, moderate breaks, and long breaks.
Intervention: Participants will complete four conditions in a randomized, counterbalanced order: sitting (uninterrupted prolonged sitting without any interruptions), short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes during the intervention). Each condition lasts 4.5 hours.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Men and women aged 18-35 years;
BMI between 18.5-24.9 kg/m2;
SB, i.e. sitting for an average of at least 9 hours per day;
Physically inactive, i.e. engaging in exercise for less than 2 to 3 times per week;
Disqualifiers
Not sedentary, i.e. sitting for less than an average of 9 hours per day;
Physically active, i.e. engaging in exercise for more than 3 times a week;
Abuse of drugs;
Use medication to treat BP, lipid, or glucose metabolism;
Trial design
Design model
Crossover
Treatments tested in this trial
Interrupting sitting with walking breaks
Other interventionParticipants will engage in 27 minutes walking in different frequencies, including short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes in one time during the intervention).
Treatment groups
33 Participants
are divided into 2 treatment groupsGroup A: Interrupting sittingExperimental treatment 1 intervention
Group B: ControlNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Mental flexibility
It will be assessed using the computer-based Trial Making Test
Time frame
baseline and 5 hours post baselineSecondary outcomes
1
Interference
Interference is assessed by the computer-based Stroop task
Time frame
baseline and 5 hours post baseline2
Memory
Memory is assessed by the computer-based n-Back Test
Time frame
baseline and 5 hours post baseline3
Attention
Attention is assessed by the paper-based d2 attention Test
Time frame
baseline and 5 hours post baseline4
Glucose metabolism
Concentration of plasma glucose will be tested.
Time frame
baseline, 30 minutes, 1 hour, 1.5 hour, 2 hour, 3 hour, 4 hour, and 5 hour post baselineSponsors and contacts
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Source ClinicalTrials.gov