Fructose and (Aging)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Vienna
About this trial
The aim of the present study is to investigate the effect of fructose consumption on health parameters and the intestinal barrier in healthy individuals
Eligibility criteria
This trial accepts healthy volunteersQualifiers
all gender, healthy collective ≥ 18 years old
Disqualifiers
Chronic inflammatory diseases of the gastrointestinal tract
Metabolic diseases or taking medication to treat metabolic diseases
Fructose malabsorption
Hereditary fructose intolerance
Trial design
Design model
Crossover
Treatments tested in this trial
Fructose
Other interventionFollowing a standardization of their nutritional intake for three days, participants will either receive a drink supplemented with low doses of free fructose (5%).
Glucose
Other interventionFollowing a standardization of their nutritional intake for three days, participants will either receive a drink supplemented with low doses of free glucose (5 %).
Treatment groups
32 Participants
are divided into 2 treatment groupsGroup A: FructoseExperimental treatment 1 intervention
Group B: GlucoseExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Changes in markers of intestinal permeability
Changes in concentrations of bacterial endotoxin in blood plasma
Time frame
At the end of the treatment (1 month)2
Cytokine release from blood immune cells stimulated with bacterial toxins
Changes in cytokine concentration in supernatant of immune cells before and after the treatments
Time frame
At the end of the treatment (1 month)Sponsors and contacts
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Source ClinicalTrials.gov