Functional digestive pathologies are defined by symptoms such as functional dyspepsia, gastroesophageal reflux, irritable bowel syndrome, gastroesophageal reflux, functional constipation, functional diarrhea, functional bloating, the opioid-induced constipation and fecal incontinence, without organic substratum. These diseases are very common in the general population (20%) and represent the first cause of consultation in city gastroenterology. The pathophysiology of these functional disorders is complex and often multifactorial: disturbances in digestive motility, altered visceral sensitivity, sphincter dysfunction, post-surgery, intestinal inflammation, dysbiosis, and impairment of the gut-brain axis. For example, it has been shown that one in four patients with inflammatory bowel disease in confirmed remission report digestive symptoms consistent with a functional bowel disorder, suggesting a possible pathophysiological continuum between these two conditions.
The objective of this study is to collect prospective clinical and tests data and a biological collection from biological samples (digestive biopsies, blood, urine and fecal samples) collected as part of the standard care. This collection could identify diagnostic or prognostic markers of the therapeutic response.
Patients over 18 years of age;
Patients with functional digestive disorder for more of 3 months;
Patients assessed as part of routine care;
Patients affiliated to the Social Security ;
Person deprived of liberty by administrative or judicial decision or major protected subject (under guardianship or curatorship);
Patients unable for any reason to read, understand, respond questionnaires (visual, psychiatric, cognitive, etc.)
Patients with functional digestive disorders consulting in our centre functional digestive disorders whether or not they are sequelae of an organic pathology.
Cohort
Prospective
Observational study
Other interventionNon interventional study
Functional digestive explorations
Gastrointestinal intraluminal pressures (mmHg), recorded during gastrointestinal manometry.
Radiological findings
Luminal dimensions (cm)
Clinical data of patients with functional digestive disorders
ethnicity (categorical measure)
Gastric emptying study
Gastric emptying time (minutes)
EndoFLIP system
Cross-sectional area (CSA) (mm²) measured using the EndoFLIP® system.
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