Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKanuni Sultan Suleyman Training and Research Hospital
About this trial
The Functional Muscle-Bone Incongruity Index (FKUI) is a novel approach developed to evaluate the relationship between muscle function and bone health. This prospective observational study aims to investigate the clinical applicability of FKUI, which combines handgrip strength, total hip bone mineral density (BMD), and lumbar-hip BMD discordance. Approximately 200 adult participants undergoing routine DXA assessment will be enrolled. The study will examine whether the combined evaluation of muscle function and bone health parameters provides a more comprehensive assessment of musculoskeletal status than individual measures alone.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or older
Attendance at the Physical Medicine and Rehabilitation outpatient clinic
Scheduled to undergo routine bone mineral density assessment by DXA as part of clinical evaluation
Ability to perform handgrip strength testing
Disqualifiers
Age younger than 18 years
Secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing syndrome, malignancy, or other conditions affecting bone metabolism)
History of metabolic bone disease
Major trauma or fracture within the previous 6 months
Trial population
The study population will consist of adults aged 18 years and older attending the Physical Medicine and Rehabilitation outpatient clinic who are scheduled to undergo routine dual-energy X-ray absorptiometry (DXA) assessment as part of their clinical evaluation. Participants will be recruited consecutively from routine clinical practice. The study aims to evaluate the relationship between muscle function and bone health through the Functional Muscle-Bone Incongruity Index (FKUI), which incorporates handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 1 trial groupGroup A: Adults Undergoing Bone Mineral Density Evaluation
Trial outcomes
Primary outcomes
1
Functional Muscle-Bone Incongruity Index (FKUI)
Assessment of the clinical applicability of the Functional Muscle-Bone Incongruity Index (FKUI), a composite index based on handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance.
Time frame
Baseline (at study enrollment)Sponsors and contacts
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Source ClinicalTrials.gov