Ga-68 FAPI PET Before Immunotherapy
ConditionMesotheliomas Pleural
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAnkara University
About this trial
It is aimed to evaluate FAP expression and its success in predicting treatment response before immunotherapy used in the treatment of malignant mesothelioma with Ga68 FAPI PET/CT imaging, which allows in vivo evaluation of FAP expression, which is thought to be associated with immunosuppression and resistance to immunotherapy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Having a histopathologically confirmed diagnosis of
Pleural Mesolthelioma
Patients scheduled for immunotherapy with anti-PDL-1 and/or anti-CTLA-4 antibodies as first or second line therapy
Patients who gave informed consent form to participate in the study
Disqualifiers
ECOG>2
Patients who did not provide informed consent form to participate in the study
Trial design
Design model
Single group
Treatments tested in this trial
Ga-68 FAPI PET/CT
Diagnostic testimaging of FAP expression of tumor before immunotherapy
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Treatment armExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Prediction of immune therapy response with Ga-68 FAPI PET
prediction of immunotherapy response with SUVmax measured with Ga-68 FAPI PET before immunotherapy
Time frame
6. month after initiation of therapy2
Prediction of immune therapy response with Ga-68 FAPI PET
prediction of immunotherapy response with total FAPI volume measured with Ga-68 FAPI PET before immunotherapy
Time frame
6. month after initiation of therapy3
Prediction of immune therapy response with Ga-68 FAPI PET
prediction of immunotherapy response with total lesion FAPI uptake measured with Ga-68 FAPI PET before immunotherapy
Time frame
6. month after initiation of therapySponsors and contacts
Click on the lead sponsor to view all of their trials.
Ankara University
Lead sponsor
Liv Hospital Ankara
Collaborator
Social Sciences University of Ankara
Collaborator
Ankara Yildirim Beyazıt University
Collaborator
Source ClinicalTrials.gov