Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Trial design

Treatments tested in this trial

• Syde

  Device DeviceA medical device, or sometimes a sham device used for comparison, that is being studied.

  Syde is an innovative device intended to be used in a home-based environment. It is composed of two watch-like sensors, each containing a magneto-inertial sensors that record the linear acceleration, the angular velocity, the magnetic field of the movement in all directions.The two watches can be worn as wristwatch or placed near the ankle.

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• Dynamometric measurements of muscle strength

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  Dynamometric measurements of the maximum force of the following functions will be taken with the MyoTools: palmar grip (MyoGrip) and thumb-index pinch (MyoPinch). Test will be realized on the dominant side. Patients will be encouraged during the test. They will be given three trials and the best score will be entered.

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• The 6-minute walk test (6MWT)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This test consists of covering the greatest possible distance within 6 minutes, walking back and forth along a 25-meter hallway. The subject may stop if they need to. The evaluator will record the elapsed time after each half-lap, and the final distance that was covered at the end of the test. No help will be allowed during the test.

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• The 10-meter test (10MWT)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  During this test, the subject must cover a distance of 10 meters as rapidly as possible. This test will be performed 3 times. The participant will be allowed to rest for one minute after the first and second instances of the test. No help will be allowed during the test.

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• The 4 stair-climbing test (4SC)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This is a standardized test during which the subject must climb the 4 stair steps as rapidly as possible. This test will be performed 3 times. The participant will be allowed to rest for one minute after the first and second instances of the test, or more if needed.

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• Test of rising from the floor (TRF)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This is a standardized test during which the subject must rise from the floor as rapidly as possible. The test starts with the participant lying on their back. This test will be performed 3 times. The participant will be allowed to rest for one minute after the first and second instances of the test.

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• The Timed up and go test (TUG)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  During this standardized test, the subject is observed and timed while he/she rises from a chair, walks 3 meters, performs a 180° turn, walk back toward the chair and sits down.

• The Progressive Supranuclear Palsy Rating Scale (PSP-RS)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This 28-item clinician-rated scale assesses motor and non-motor symptom severity in patients with PSP, with a score ranging from 0 (normal) to 100.

• The Montreal Cognitive Assessment (MOCA)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  The MOCA was designed as a rapid screening instrument for mild cognitive dysfunction. It assesses different cognitive domains: attention and concentration, executive function, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation. Scores on the MOCA range from 0 to 30, with higher score being better outcome.

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• The Charcot-Marie-Tooth examination score (CMTES)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  The CMTES is a 28-point composite score that rates the patient's symptoms and signs. It is part of the Charcot-Marie-Tooth (CMT) neuropathy score and has been validated as a reproducible measure of disability in CMT. Higher scores indicate more severe neuropathy.

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• 9-Hole Peg Test (9-HPT)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  The 9-HPT is a quantitative test of upper limb function. It is the second component of the Multiple Sclerosis Functional Composite (MSFC). The patient sits at a table with a shallow container containing nine sticks and a wooden or plastic block containing nine empty holes. When a timer is started, the patient places the nine sticks one after the other as quickly as possible into the nine holes and, once they are all in the holes, removes them as quickly as possible. The total time taken to complete the task is recorded. Two consecutive attempts with the dominant hand are immediately followed by two consecutive attempts with the non-dominant hand.

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• The Unified Huntington's Disease Rating Scale (UHDRS)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This 74-item clinical rating scale assesses patient performance and capacity in 4 domains: motor function, cognitive function, behavioral abnormalities, and functional capacity.

• Quantitative Myasthenia Gravis (QMG)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  The QMG is a clinician-rated 13-item scale used to quantify disease severity in patients with MG. The scale grades each domain (ocular, bulbar, respiratory, and limb function), with a total score ranging from 0 to 39 (lower score indicating a better clinical outcome).

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• The Myasthenia Gravis Activities of Daily Living Scale (MG-ADL)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This is an 8-item patient-reported scale assessing MG symptoms and their effects on daily activities. The score ranges from 0 to 24, with higher score indicating a worse clinical outcome.

• The Scale for the Assessment and Rating of Ataxia (SARA)

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  This 8-item scale was developed to assess ataxia severity and disease progression. It evaluates gait and balance, speech, and upper and lower limb coordination. The score ranges from 0 to 40, with higher score indicating a worse clinical outcome.

• Patient's Global Impression of Change (PGIC)

  Other intervention Other interventionAn intervention that does not fit one of the standard intervention types.

  PGIC is a patient-reported scale used to assess how a patient feels their condition has changed over time. It typically uses a 7-point scale to capture the patient's overall perception of improvement in symptoms, function, and quality of life.