Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRoyal Marsden NHS Foundation Trust

About this trial

The INDAGA-UK trial is a retrospective, multi-centre observational study in participants with locally advanced and recurrent salivary gland to investigate t its molecular profiling, and to explore new prognostic and druggable markers. We will analyse samples and data from patients diagnosed with salivary gland cancer from 2013 - 2023. Subject and sample identification will occur over a 12-month period. Samples and data will be analysed over the next 12 months prior to study end.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged over 18

Histological diagnosis of salivary gland cancer (SGCs)

Availability of archival tissue (acceptable after 2013 up to present)

Ability to give informed consent (if applicable)* for retrieving histological specimen and preform molecular analysis *De-identified archival tissue from deceased patients will be collected as part of the study once REC approval is in place, if the patient was alive when the samples were taken and they are not part of the NHS opt out scheme.

Disqualifiers

Different H&N cancer of other histology

Thyroid cancers

Trial population

Participants with a salivary gland cancer diagnosis

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • Observation

    Other intervention

    Observational study, no intervention

Treatment groups

250 Participants
are divided into 1 treatment group
Group A: Cohort 11 intervention

Trial outcomes

Primary outcomes

1

• Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.

• Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.

Time frame
Time Frame: Through study completion, expected duration of 10 years

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: