General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-18
SponsorPeking University First Hospital
About this trial
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital.
Disqualifiers
Preterm patients;
Height and weight not within the standard ranges for respective ages;
Surgery for head or heart;
Patients with muscular, neurologic or psychiatric diseases;
Trial population
patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
propofol
DrugGeneral anesthesia is induced and maintained mainly with propofol.
sevoflurane
DrugGeneral anesthesia is induced and maintained mainly with sevoflurane.
S-ketamine
DrugGeneral anesthesia is induced mainly with S-ketamine and maintained mainly with propofol.
Treatment groups
366 Participants
are divided into 3 treatment groupsGroup A: propofol1 intervention
Group B: sevoflurane1 intervention
Group C: ketamine1 intervention
Trial outcomes
Primary outcomes
1
phase-amplitude coupling
phase-amplitude coupling
Time frame
induction, maintenance, and recovery of anesthesia2
bicoherence
bicoherence
Time frame
induction and maintenance, and recovery of anesthesia3
spectral analysis
spectral analysis
Time frame
induction and maintenance, and recovery of anesthesia4
entropy indices
entropy indices
Time frame
induction and maintenance, and recovery of anesthesiaSponsors and contacts
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Source ClinicalTrials.gov