Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.
Adults: Age more than or equal to 18; an equal number of Males and Females
Consent to the collection of genetic material
Willing to adhere to the study protocol
Age <18, at screening.
BMI >45 kg/m2.
Blood pressure more than 140/90 mmHg.
Participants who are taking more than 2 hypertension medications.
Parallel
Study diet
Dietary supplementParticipants will consume the study diet for 5 days provided by the clinical research unit's metabolic kitchen (at UAB)
Exercise capacity VO2 max determination
Other interventionEach participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol and will also undergo a DEXA scan to determine the body mass.
Exercise Challenge
Other interventionEach participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill and will also undergo a resting energy expenditure test.
Glucose Challenge
Other interventionParticipants will come in fasting state on day 6th and will be given 75 gm oral glucose solution to drink, followed by blood collection every hour for next 8 hours.
Change in MRproANP levels following a standardized oral glucose challenge between the high genotype group and low genotype group.
Change in Exercise Energy Expenditure between the high genotype and low genotype group.
Change in miR-425 levels following a standardized oral glucose challenge in those with low ANP genotype.
Change in miR-425 levels following a standardized exercise challenge in those with low ANP genotype.
Change in the NPs (ANP, BNP, NTproBNP) following the glucose challenge between the high genotype group and low genotype group.
Change in the serum glucose following the glucose challenge between the high genotype group and low genotype group.
Change in the serum insulin following the glucose challenge between the high genotype group and low genotype group.
Change in Resting Energy Expenditure (REE) between the two genotype groups.
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University of Alabama at Birmingham
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
