Genetic Basis of Melanocytic Nevi
ConditionMelanocytic Nevi
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of California, Davis
About this trial
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.
Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:
1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Male or female subjects that are 18 years or older
Subjects with melanocytic nevi\
Disqualifiers
Patients less than 18 years of age
Patients without melanocytic nevi
Patients with a bleeding disorder or are taking anticoagulation medication
Trial population
Subjects seen in UC Davis dermatology clinic diagnosed as having melanocytic nevi will be recruited from the clinic during their routine visit. Subjects identified in clinic will be approached after their clinic visit.
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Collecting Nevi
Other interventionWill be collecting Nevi and completing a DNA analysis, no intervention will be made.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Genome Wide Mutation Analysis
Will be performing genome wide mutation analysis to quantify the number of mutations.
Time frame
Feb 2017 - December 2018Sponsors and contacts
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Source ClinicalTrials.gov