Genetic Characterization of Movement Disorders and Dementias
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-120
SponsorNational Institute on Aging (NIA)
About this trial
Background:
There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes. On the other hand, dementia is a condition of declining mental abilities, especially memory. Dementia can occur at any age but becomes more frequent with age. Researchers want to study the genes of families with a history of movement disorders or dementia. They hope to find a genetic cause of these disorders. This can help them better understand and treat the diseases. This study will not be limited to a particular disorder, but will study all movement disorders or dementias in general. This study will perform genetic testing to identify the genetic causes of movement disorders and dementia. Today, genetic testing can be done to analyze multiple genes at the same time. This increases the chances of finding the genetic cause of movement disorders and dementias.
Objectives:
To learn more about movement disorders and dementia, their causes, and treatments.
Eligibility:
Adults and children with a movement disorder or dementia, and their family members.
Healthy volunteers.
Design:
Participants will be screened with medical history and blood tests. Some will have physical exam.
Participants will give a blood sample by a needle in the arm. This can be done at the clinic, by their own doctor, or at home. Alternatively, a saliva sample may be provided if a blood sample cannot be obtained.
Participants can opt to send an extra blood sample to a repository for future study. Genetic test will be done on these samples. The samples will be coded. The key to the code will remain at NIA. Only NIA investigators will have access to the code key. Participants can request to receive results of the tests.
Participation is generally a single visit. Participants may be called back for extra
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Diagnosis of a movement disorder or dementia by a neurologist or other qualified professional and accompanied by sufficient clinical and/or laboratory evidence to support the diagnosis
Confirmation of a movement disorder or dementia by study investigators or a qualified clinician by physical examination and/or review of medical records
Ages 18 and above
Able to provide consent or, in the case of subjects without consent capacity, have a legally authorized representative to provide consent
Disqualifiers
Clinically significant anemia that would make phlebotomy unsafe, and participant unwilling to provide saliva sample.
Clinically significant bleeding that would make phlebotomy unsafe, and participant unwilling to provide saliva sample.
Any medical condition that would make phlebotomy unsafe or undesirable, such as a serious medical illness like unstable heart disease, or unstable chronic obstructive pulmonary disease, and participant unwilling to provide saliva sample.
Trial population
Participants with confirmed or suspected movement disorder or dementia diagnosis and their affected and unaffected family members will be potential candidates for the study, well as unrelated, healthy individuals (known as control samples. Where there is no logical upper limit, we plan to enroll 12,000 study subjects (10,000 patients, 1,000 asymptomatic family members, 1,000 neurological normal controls) for this study.
Trial design
Design model
Case-control
Time perspective
Other
Treatments tested in this trial
Not listed
Trial groups
12,000 Participants
are grouped into 2 trial groupsGroup A: 1
Group B: 2
Trial outcomes
Primary outcomes
1
Finding genetic cause of disease
Causative for the movement disorder or dementia that the patient has been diagnosed with.
Time frame
Identification of pathogenic genetic variantsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov