Genetic of Skeletal Muscle Insulin Resistance
ConditionInsulin Stimulated
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorThe University of Texas Health Science Center at San Antonio
About this trial
In this study, we will use euglycemic/hyperinsulinemic clamps, longitudinal skeletal muscle biopsies, and single nucleus RNA- and ATAC- sequencing to reveal cell type-specific molecular response Quantitative trait loci (rQTLs) acutely regulated by insulin signaling and glucose uptake.
Eligibility criteria
Qualifiers
Males and Females Age 18-75
Body Mass Index (BMI) > 18
Hemoglobin A1c < 5.7
Creatinine < 2
Disqualifiers
Urine albumin excretion>300mg/day
Partial thromboplastin time (PTT) >35International normalized ratio (INR) > 1.2
No oral corticosteroids for 1 month
No Sodium-glucose co-transporter 2 (SGLT2) inhibitor for 3 months
Trial design
Treatments tested in this trial
- Insulin 80mU/m2*min
Treatment groups
100 Participants
are divided into 1 treatment groupSponsors and collaborators
The University of Texas Health Science Center at San Antonio
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov