Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
ConditionParkinson Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJay Alberts
About this trial
The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.
Eligibility criteria
Qualifiers
Adult with a diagnosis of PD by a physician or physician extender
Hoehn and Yahr stage I-III
Demonstrate the ability to safely mount and dismount a stationary cycle
Reliable transportation to the community exercise facility
Disqualifiers
Participation in disease modifying PD-related clinical trial or study
Diagnosis of dementia or any neurocognitive impairment that compromises one's ability to provide informed consent.
Implanted deep brain stimulation electrodes or focused ultrasound for PD management
Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen a. If the ACSM screen recommends medical clearance, the participant must obtain medical clearance by their health care provider prior to participation.
Trial design
Treatments tested in this trial
- High intensity stationary cycling
Treatment groups
200 Participants
are divided into 1 treatment groupSponsors and collaborators
Jay Alberts
Lead sponsor
The Cleveland Clinic
Sponsor institution
National Institutes of Health (NIH)
Collaborator
Source ClinicalTrials.gov