Genetics in the Progression of Nephropathies

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorOspedale San Raffaele

About this trial

This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to:

* AKI * CKD * Hypertension * ADPKD * CKD-MBD * Patients with decompensated heart failure undergoing either medical or surgery therapy * Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation * glomerular diseases

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

to be evaluated in the different sub-protocols

Trial population

This study will evaluate different groups of adult patients: 1. Patients with chronic nephropathy 2. Patients with acute nephropathy 3. Patients with nephrectomy 4. Candidate Patients to major surgery 5. Patients with decompensated heart failure undergoing either medical or surgical therapy 6. Acute critically ill patients (e.g sepsis, post-operative) 7. Patients with hypertension 8. Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation. 9. Long-term surviving patients who received bone marrow transplantation.

Trial design

Design model

Other

Time perspective

Other

Treatments tested in this trial

  • genetic polymorphisms

    Genetic

Treatment groups

10,000 Participants
are divided into 1 treatment group
Group A: Patients with acute or chronic nephropathy1 intervention

Trial outcomes

Primary outcomes

1

difference in glomerular filtration rate according to genetic profile

eGFR value

Time frame
from days to 35 years

Secondary outcomes

Other outcomes

Sponsors and contacts

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