Global Cardio Oncology Registry

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe Cleveland Clinic

About this trial

G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increased incidence of cancer therapy related cardiovascular toxicity (CTR-CVT) in different settings and to derive and validate risk scores for cardio oncology patients treated in different geographic locations throughout the world.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

New cardio-oncology consultation for breast cancer patients, or

New cardio-oncology consultation for Hodgkin's or non-Hodgkin's lymphoma patients, or

New cardio-oncology consultation for acute or chronic leukemia patients, or

New cardio-oncology consultation for multiple myeloma or AL amyloidosis, or

Disqualifiers

Cardio-oncology patients who have previously had cardio-oncology evaluation and follow up by the investigators.

Minors less than 18 years old.

Inability or unwillingness to consent to participate

Trial population

As above

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • anonymized data collection during programmed surveillance clinical follow up

    Other intervention

    anonymized data entry of demographic, clinical, imaging, laboratory, cancer treatment, and cardiovascular events into a RedCap Cloud platform

Treatment groups

5,000 Participants
are divided into 3 treatment groups
Group A: Breast cancer1 intervention
Group B: Hematological malignancies1 intervention
Group C: Immune check point inhibitors1 intervention

Trial outcomes

Primary outcomes

1

Cardiotoxicity

Any new cardiac event occurring during or after cancer treatment

Time frame
18 months of prospective follow up
2

New cardiovascular events

Heart failure, myocardial infarction, cardiac arrhythmias, syncope, coronary revascularization, heart transplant, cerebrovascular accident, peripheral arterial disease, hypertension, pulmonary hypertension. All events will be adjudicated according to standard clinical definitions.

Time frame
18 months of prospective follow up
3

Cardiovascular death.

Death during or after cancer treatment, adjudicated to cardiovascular causes by treating physicians.

Time frame
18 months of prospective follow up

Secondary outcomes

Other outcomes

Sponsors and contacts

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