Glucose-fructose Ratio Pilot
ConditionExercise Metabolism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Bath
About this trial
The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age: 18 years and above;
Performing endurance training for at least 5 hours per week
Capable of three hours of continuous exercise
Disqualifiers
Glucose or lipid lowering, or weight loss medication
Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
Contraindications to exercise
Pregnant or lactating
Trial design
Design model
Crossover
Treatments tested in this trial
Glucose and fructose (one-to-one)
Other interventionGlucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)
Glucose and fructose (two-to-one)
Other interventionGlucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)
Treatment groups
10 Participants
are divided into 2 treatment groupsGroup A: One to One ratioExperimental treatment 1 intervention
Group B: Two to one ratioActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Exogenous carbohydrate oxidation rate (g/h)
Total exogenous carbohydrate oxidation rate (g/h) over 180 minutes
Time frame
180 minutesSecondary outcomes
1
Peak exogenous carbohydrate oxidation rate (g/h)
Highest recorded exogenous carbohydrate oxidation rate (g/h)
Time frame
180 minutes2
Whole-body carbohydrate oxidation rate (g/h)
Total whole-body carbohydrate oxidation rate (g/h)
Time frame
180 minutes3
Endogenous carbohydrate oxidation rate (g/h)
Total endogenous carbohydrate oxidation rate (g/h)
Time frame
180 minutes4
Whole-body fat oxidation rate (g/h)
Total whole-body fat oxidation rate (g/h)
Time frame
180 minutesOther outcomes
1
Exogenous carbohydrate oxidation over 2 hours (g/h)
Total exogenous carbohydrate oxidation over 2 hours (g/h)
Time frame
120 minutesSponsors and contacts
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Source ClinicalTrials.gov