This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.
Aged 50 years and older
At least 8th grade education
Diagnosed type 1 or type 2 diabetes
Current use of mediation for diabetes (oral hypoglycemic agents, insulin), or with diabetic properties (e.g., steroids)
Chronic disorders (cardiovascular disease, peripheral vascular disease, stroke, transient ischemic attack, chronic kidney disease, past year cancer)
Neurological disorders (e.g., Parkinson's, epilepsy, multiple sclerosis)
Adults aged 50 years and older with prediabetes of any duration
Ecologic or community
Cross-sectional
Continuous Glucose Monitoring System (CGMS)
DeviceContinuous Glucose Monitoring System (CGMS)- minimally invasive sensors that measure glucose concentrations at 5-min intervals over several days.
Aggregate Executive Functioning Score
Scores on the following standard neurocognitive tests will be z-transformed based on their respective means and standard deviations and combined into one aggregate total score such that higher values mean better executive functioning: Trails Making A and B, The Stroop-Color Word Test, Digit Span subscale of the Wechsler Adult Intelligence Scale - Revised (WAIS-IV), Digit Symbol Substitution Test (DSST)
Aggregate Memory Score
Scores on the following standard neurocognitive tests will be z-transformed based on their respective means and standard deviations and combined into one aggregate total score such that higher values mean better memory ability: California Verbal Learning Test, Benton Visual Retention Test
Aggregate Language Score
Scores on the following standard neurocognitive tests will be z-transformed based on their respective means and standard deviations and combined into one aggregate total score such that higher values mean better language abilities: Boston Naming Test, Controlled Oral Word Association Test (COWA)
Aggregate Physical Functioning Score
Scores on the following standard neurocognitive tests will be summed into one aggregate total score such that higher values mean better physical functioning: gait speed, short physical performance battery (SPPB), handgrip strength, and four-square step test
Activities of Daily Living (ADL) total score
Responses on this standard measure will be scored according to guidelines to create a total score for functional status
Instrumental Activities of Daily Living (IADL) total score
Responses on this standard measure will be scored according to guidelines to create a total score for functional status
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University of Maryland, Baltimore
Lead sponsor
Baltimore VA Medical Center
Collaborator
University of Maryland, Baltimore County
Collaborator
