Glycemic Control Following Occupational Work in a Hot Environment
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorLoughborough University
About this trial
Occupational workers regularly perform physically demanding tasks in hot environments, exposing them to heat stress and potential dehydration. While the physiological impacts of heat exposure are well-documented, its effects on glycemic control remain less understood. Given the rising global temperatures due to climate change and the increasing prevalence of metabolic disorders such as obesity and type 2 diabetes, it is essential to investigate how heat exposure during work influences glycemic regulation. Understanding these interactions will help inform future occupational health guidelines and metabolic health recommendations in physically demanding industries.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male or female
Generally fit and healthy
Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week
Disqualifiers
Under 18 or 45 and over,
any morbidity or medication that might influence carbohydrate/fat metabolism (i.e., liver/renal/cardiovascular disease) or cycling ability (musculoskeletal injury etc),
coagulation or bleeding disorders,
blood-borne illness,
Trial design
Design model
Crossover
Treatments tested in this trial
Hot environment
Other interventionParticipants exercising in a 36 degrees celsius environment
Temperate condition
Other interventionParticipants exercising in a 18 degrees celsius environment
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: Hot conditionExperimental treatment 1 intervention
Group B: Temperate conditionExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Plasma glucose
Measured using colorimetric assay from venous blood samples
Time frame
8hoursSecondary outcomes
1
Plasma insulin
Measured using ELISA from venous blood samples
Time frame
8hours2
Plasma osmolality
Measured using freezing point depression from venous blood samples
Time frame
8hours3
Plasma volume change
Determined from haemoglobin and haematocrit measures in blood samples
Time frame
8hours4
Urine volume
Determined from urine samples collected before and after exercise
Time frame
8hoursOther outcomes
1
N-back task for working memory (cognitive function)
The task will comprise three progressively harder memory loads (1-Back, 2-Back, 3-Back). Each stimulus type will be used in all memory loads. Participants will have to respond using the space bar when they see a stimulus that is presented one, two, or three steps previously, dependent on the load condition.
Time frame
8hours2
Go/no-go task for response inhibition (cognitive function)
Participants will be instructed to press the space bar when a green image appears onscreen ("go" stimulus) and to inhibit responding when a red image is presented (the "no-go" stimulus). Increased commission error responses (i.e. responding incorrectly on a no-go trial) will indicate reduced response inhibition. Commission errors and correct responses will be measured as indices of performance.
Time frame
8hours3
Stroop test
The Stroop Test is a psychological assessment that measures a person's ability to inhibit cognitive interference and control attention. Typically, it involves naming the color of the ink in which a word is printed, even when the word itself names a different color (e.g., the word "red" printed in blue ink). The delay in response time when the word and ink color do not match-known as the Stroop effect-reflects the difficulty of suppressing automatic cognitive processes.
Time frame
8hoursLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: