Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorBall State University

About this trial

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18 - 45 years.

Body mass index between 18.5-35.0 kg/m2

Not pregnant (females only)

Not postmenopausal (females only).

Disqualifiers

Not between the ages of 18-45

Body mass index < 18.5 kg/m2 or >35.0 kg/m2

Pregnant (females only)

Postmenopausal status (females only).

Trial design

Design model

Crossover

Treatments tested in this trial

  • Low-Glycemic Breakfast Containing Oats and Mango

    Other intervention

    Low-glycemic breakfast of 80 grams of oats prepared with 473mL water and sweetened with 146 grams of mango.

  • High-Glycemic Breakfast Containing Cereal and Mango

    Other intervention

    High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 262 grams of mango.

  • Low-Glycemic Breakfast Containing Oats and Table Sugar

    Other intervention

    Low-glycemic breakfast of 80 grams of oats prepared with 473mL of water and sweetened with 20 grams of table sugar.

  • High-Glycemic Breakfast Containing Cereal and Table Sugar

    Other intervention

    High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 36 grams of table sugar.

Treatment groups

24 Participants
are divided into 4 treatment groups
Group A: Cereal Consumption with MangoExperimental treatment 1 intervention
Group B: Cereal Consumption with Table SugarExperimental treatment 1 intervention
Group C: Oat Consumption with MangoExperimental treatment 1 intervention
Group D: Oat Consumption with Table SugarExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Glucose

The investigators will measure glucose at baseline and .5-, 1-, 2-, and 3-hours after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

Time frame
Through study completion, up to 1.5 years.
2

Insulin

The investigators will measure insulin at baseline and .5- 1-, 2-, and 3-hours after each meal containing. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

Time frame
Through study completion, up to 1.5 years.
3

Flow-mediated Dilation

The investigators will measure FMD at baseline and 1-, 2-, and 3-hours after the meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

Time frame
Through study completion, up to 1 year.

Secondary outcomes

1

HDL-C

The investigators will measure HDL-C at baseline and .5-, 1-, 2-, and 3-hours after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

Time frame
Through study completion, up to 1 year.
2

Triglycerides

The investigators will measure triglycerides at baseline and .5-, 1-, 2-, and 3-hours after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.

Time frame
Through study completion, up to 1 year.
3

Acceptability

The investigators will measure acceptability of each meal with a survey at each study visit once post-meal.

Time frame
Through study completion, up to 1 year.
4

Satiety

The investigators will measure satiety through a survey at baseline and at .5-, 1-, 1.5-, 2-, 2.5-, and 3-hours after the meal.

Time frame
Through study completion, up to 1 year.

Other outcomes

1

Body Composition

The investigators will measure body composition using bioelectrical impedance (InBody).

Time frame
Through study completion, up to 1 year.
2

Systolic and Diastolic Pressure

The investigators will measure blood pressure using an automated cuff (Omron).

Time frame
Through study completion, up to 1 year.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ball State University

Lead sponsor

National Mango Board

Collaborator