Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-39
SponsorTechnical University of Munich
About this trial
The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Body Mass Index (BMI) between 20-29 kg/m2
No structured resistance training performed in the last twelve months.
Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.
No history of competitive strength or physique sports.
Disqualifiers
Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.
Positive response to any question on the PAR-Q 2025 questionnaire.
Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.
Regular engagement in shift work.
Trial design
Design model
Single group
Treatments tested in this trial
Hypertrophy-focused Resistance Training
BehavioralStandardized training consisting of twice-weekly supervised sessions for 8 weeks. Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions. Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.
Treatment groups
120 Participants
are divided into 1 treatment groupGroup A: Resistance Training GroupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Change in mid-thigh Muscle Thickness
Change in mid-thigh muscle thickness (combination of rectus femoris and vastus intermedius) as measured by ultrasound.
Time frame
Baseline and Week 8 (completion of training intervention)2
Change in lateral-thigh Muscle Thickness
Change in lateral thigh muscle thickness (combination of vastus lateralis and vastus intermedius) as measured by ultrasound.
Time frame
Baseline and Week 8 (completion of training intervention)Secondary outcomes
1
Change in Peak Rate of Blood Lactate Accumulation (vLapeak)
Peak rate of blood lactate accumulation before and after a 10-second all-out seated cycle ergometry test. Blood lactate will be sampled every minute for 10 minutes post-test to capture the peak value.
Time frame
Baseline and Week 8 (completion of training intervention)2
Change in Vastus Lateralis Muscle Cross-Sectional Area (CSA)
Change in cross-sectional area of the vastus lateralis at 50% of muscle length measured via ultrasound.
Time frame
Baseline and Week 8 (completion of training intervention)3
Maximal Strength (3RM) for Leg Press
Change in 3-Repetition Maximum (3RM) for the leg press exercise to assess lower-body multi-joint maximal strength.
Time frame
Baseline and Week 8 (completion of training intervention)4
Maximal Strength (3RM) for Leg Exentsion
Change in 3-Repetition Maximum (3RM) for the leg extension exercise to assess single-joint quadriceps strength.
Time frame
Baseline and Week 8 (completion of training intervention)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Technical University of Munich
Lead sponsor
Chemnitz University of Technology
Collaborator
DLR German Aerospace Center
Collaborator
University of Jyvaskyla
Collaborator
University of Limerick
Collaborator
IST University of Applied Sciences Düsseldorf
Collaborator
Institute for Applied Training Science (IAT/FES e.V.)
Collaborator
Source ClinicalTrials.gov