GRoup A StrePtococcus

ConditionStreptococcal Pharyngitis

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age5-15

SponsorUniversity of Wisconsin, Madison

About this trial

The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Children ages 5-15 years

Positive rapid antigen detection test for group A streptococcus

Parent or legal guardian present and able to provide consent

Provider prescribes treatment with a beta lactam antibiotic

Disqualifiers

Unable to take beta lactam antibiotics

Other concurrent bacterial infection, i.e., pneumonia

Trial population

Children will be eligible for this study if they are ages 5 to 15 years and have been diagnosed to have acute pharyngitis caused by GAS (with a positive rapid antigen detection test (RADT). Children will be excluded if they are unable to take beta lactam antibiotics. Children will be enrolled at UW Health sites in Madison, Wisconsin, including both pediatric ambulatory care clinics and urgent care clinics. The study team will offer participants the option to complete follow-up study visits in-clinic

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Identifying group A strep carriers
Other intervention
At study entry, at 14 days, and if follow up is positive, again in 14-21 days: Standard culture for GAS and analysis of mRNA.

Treatment groups

180 Participants

are divided into 1 treatment group

Group A: Rapid Strep Positive1 intervention

Trial outcomes

Primary outcomes

Identifying children who are pharyngeal carriers of Group A streptococcus

The specific aim of this study is to identify 30 children with acute pharyngitis due to Group A streptococcus (GAS) and 30 children who are pharyngeal carriers of GAS. Thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between October and May will have a positive culture or rapid antigen detection test for GAS. Approximately 10-15% of these children with pharyngitis and a positive culture or rapid antigen detection test (RADT) for GAS will be carriers

Time frame

2 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Wisconsin, Madison

Lead sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Collaborator

Source ClinicalTrials.gov

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