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Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging

ConditionsExercise TrainingAging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-65
SponsorUniversity of Kansas Medical Center

About this trial

The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out.

Participants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

speak English

have access to reliable communication (a telephone or cell phone, computer, etc.)

normal or corrected to normal vision and hearing

ambulatory (without the use of assistive devices)

Disqualifiers

patients with arrhythmias or acute cardiac events will be excluded due to potential complications with the supervised moderate exercise

at risk for hazard due to magnetic fields due to MR safety concerns

have any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder)

have history of seizures or head trauma due to MR data quality

Trial design

Design model

Factorial

Treatments tested in this trial

  • Episodic Future Thinking

    Behavioral

    During the audio recorded guided imagery exercise participants will be asked to think in detail of a future (6 months to a year) where they have made healthy choices regarding physical activity and are physically active.

  • Episodic Recent Thinking

    Behavioral

    During the audio recorded guided imagery exercise participants will be asked to think about a routine weekly activity.

  • Positive Affective Imagery

    Behavioral

    During the audio recorded guided imagery exercise participants will be asked to think in detail about the positive outcomes and sensations associated with an exercise bout.

  • Neutral Affective Imagery

    Behavioral

    During the audio recorded guided imagery exercise participants will be asked to think in detail about the physical sensations associated with an exercise bout.

  • HIIT Exercise Intervention

    Behavioral

    The high intensity interval training (HIIT) will be conducted 2 times per week for 6 weeks. The duration of each individual exercise session will last about 45 minutes. After the 5-minute warm-up at 30% peak workload, HIIT will consist of repeated 1-minute high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 80% of peak watts (range: 75%-85%) followed by the "off" interval at 10% of peak watts. The session will end with up to 10 minute cool-down at 20% peak workload.

Treatment groups

160 Participants
are divided into 4 treatment groups
Group A: Episodic Future Thinking (EFT) + Positive Affective Imagery (PAI)Experimental treatment 3 interventions
Group B: Episodic Future Thinking (EFT) + Neutral Affective Imagery (NAI)Experimental treatment 3 interventions
Group C: Episodic Recent Thinking (ERT) + Positive Affective Imagery (PAI)Experimental treatment 3 interventions
Group D: Episodic Recent Thinking (ERT) + Neutral Affective Imagery (NAI)Active comparator 3 interventions

Trial outcomes

Primary outcomes

1

Adherence to HIIT exercise

Adherence will be calculated as percent sessions attended each week and percent minutes during which the participant adhered to the HIIT protocol.

Time frame
1 to 6-weeks
2

The Monetary-Choice Questionnaire

The Monetary-Choice Questionnaire is a 27-item self-administered questionnaire. For each item, the participant chooses between a smaller, immediate monetary reward and a larger, delayed monetary reward. The investigators will behaviorally assess participants' preferences for immediately available smaller rewards vs. delayed larger rewards.

Time frame
1 to 6-weeks
3

Positive Affect

The Feeling Scale is a single item measure of core affect on which participants are asked to rate their current feelings on an 11-point scale ranging from -5 (very bad) to 5 (very good).

Time frame
1 to 6-weeks

Secondary outcomes

1

Percent signal change in Functional Connectivity Neuroimaging

The investigators will assess % signal changes in brain connectivity between reward and regulation brain regions following intervention.

Time frame
1 to 6-weeks

Other outcomes

1

Number of Participants with Alzheimer's Disease Risk

Genetic risk for Alzheimer's disease will be measured by examining APOE4 carrier status.

Time frame
Baseline
2

The Monetary-Choice Questionnaire

The Monetary-Choice Questionnaire is a 27-item self-administered questionnaire. For each item, the participant chooses between a smaller, immediate monetary reward and a larger, delayed monetary reward. The investigators will behaviorally assess participants' preferences for immediately available smaller rewards vs. delayed larger rewards.

Time frame
1 to 12 weeks
3

Positive Affect

The Feeling Scale is a single item measure of core affect on which participants are asked to rate their current feelings on an 11-point scale ranging from -5 (very bad) to 5 (very good).

Time frame
1 to 12 weeks
4

Amount of Daily Moderate to Vigorous Physical Activity (MVPA minutes)

The investigators will measure physical activity (MVPA minutes) at baseline, end of intervention, and end of follow-up using accelerometers worn daily for 10-14 days.

Time frame
1 to 12 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Kansas Medical Center

Lead sponsor

National Institute on Aging (NIA)

Collaborator

Source ClinicalTrials.gov
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