Half-dose vs Conventional-dose Cetrorelix in ICSI Cycles
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-34
SponsorAssiut University
About this trial
This prospective cohort study aims to compare the effectiveness of half-dose (0.125 mg/day) versus conventional-dose (0.25 mg/day) cetrorelix in GnRH antagonist ICSI cycles regarding clinical pregnancy rate in women with BMI ≥25 kg/m².
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
- Age less than 35 years
Normal ovarian responders (AMH ≥1.2 ng/mL and AFC 5-15)
Body mass index (BMI) ≥25 kg/m²
Written informed consent
Disqualifiers
- Age greater than 35 years
Diminished ovarian reserve (AMH <1.2 ng/mL or AFC <5)
Congenital uterine anomalies or significant intrauterine pathology
Contraindications to ovarian stimulation or pregnancy
Trial population
Women aged less than 35 years with BMI ≥25 kg/m² and normal ovarian reserve who received either half-dose or conventional-dose cetrorelix as part of routine care during GnRH antagonist ICSI cycles at Assiut University Hospital.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
160 Participants
are grouped into 2 trial groupsGroup A: Half-dose Cetrorelix 0.125 mg
Group B: Conventional-dose Cetrorelix 0.25 mg
Trial outcomes
Primary outcomes
1
Clinical Pregnancy Rate
Proportion of women with intrauterine gestational sac with fetal heartbeat by ultrasound at 6 weeks gestation
Time frame
6 weeks after embryo transferSecondary outcomes
1
Ongoing pregnancy rate
Ongoing pregnancy with heartbeat \>12 weeks on ultrasound
Time frame
12 weeks after embryo transfer2
Number of retrieved oocytes
Mean number of oocytes retrieved at pickup
Time frame
Periprocedurally, at time of oocyte retrieval, during oocyte pickup procedure3
Number of mature MII oocytes
Mean number of mature MII oocytes
Time frame
Periprocedurally , at time of oocyte retrieval, Day 0, during oocyte pickup procedure4
Fertilization rate
Fertilized oocytes / MII oocytes
Time frame
1 day after ICSILocations
Sponsors and contacts
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Source ClinicalTrials.gov
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