HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorÖmer Faruk Okumuş
About this trial
This observational clinical study aims to investigate the relationship between the HALP score (Hemoglobin × Albumin × Lymphocyte / Platelet), several blood-based inflammatory indices (including NLR, PLR, LMR, and SII), and salivary MMP-8 levels in individuals with periodontal health, gingivitis, and stage III/IV periodontitis. The study also evaluates how these biomarkers relate to healing following non-surgical periodontal therapy.
A total of 180 participants aged 18-65 years will be included: 50 healthy individuals, 50 patients with gingivitis, and 80 patients with stage III/IV periodontitis. All participants will undergo periodontal clinical examination and provide blood and saliva samples at baseline. Individuals in the gingivitis and periodontitis groups will receive standard non-surgical periodontal treatment (full-mouth debridement) and will return for a 3-month follow-up visit, where periodontal measurements will be repeated. In the periodontitis group, an additional blood sample will be collected at the 3-month follow-up visit.
The primary objective is to determine whether baseline HALP score, systemic inflammatory indices, and salivary MMP-8 levels differ between participants who show good versus poor healing after treatment. Secondary objective include comparing biomarker levels across periodontal status groups. The findings may contribute to early prediction of treatment response and personalized periodontal care.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 18-65 years
Ability to provide informed consent
No systemic diseases or conditions affecting periodontal status
For Healthy Group: Probing depth ≤3 mm, no attachment loss, no radiographic bone loss
Disqualifiers
Systemic diseases influencing periodontal inflammation (e.g., diabetes, autoimmune disorders)
Current pregnancy or lactation
Use of antibiotics, anti-inflammatory medications, or immunosuppressive drugs within the last 3 months
Smokers or individuals using tobacco products
Trial population
Adult individuals aged 18-65 years presenting to the periodontology clinic for routine examination or periodontal treatment. Participants will be assigned to healthy, gingivitis, or stage III/IV periodontitis groups based on periodontal diagnosis.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Non-surgical Periodontal Therapy
Procedure/SurgeryStandard full-mouth supra- and subgingival debridement performed in a single session, followed by oral hygiene instructions.
Treatment groups
180 Participants
are divided into 3 treatment groupsGroup A: Periodontally Healthy Individuals1 intervention
Group B: Gingivitis Patients1 intervention
Group C: Stage III/IV Periodontitis Patients1 intervention
Trial outcomes
Primary outcomes
1
Differences in Baseline HALP Score Between Good and Poor Treatment Responders
Evaluation of whether baseline HALP score differs between good responders (\>2 mm reduction in probing depth at sites ≥5 mm) and poor responders (≤2 mm reduction) following non-surgical periodontal therapy in periodontitis patients.
Time frame
Baseline (T0) to 3 months after treatment (T2)Secondary outcomes
1
Differences in Baseline NLR Between Good and Poor Responders
Comparison of baseline neutrophil-to-lymphocyte ratio between good and poor responders in the periodontitis group.
Time frame
Baseline (T0)2
Differences in Baseline PLR Between Good and Poor Responders
Comparison of baseline platelet-to-lymphocyte ratio between good and poor responders in the periodontitis group.
Time frame
Baseline (T0)3
Differences in Baseline LMR Between Good and Poor Responders
Comparison of baseline lymphocyte-to-monocyte ratio between good and poor responders in the periodontitis group.
Time frame
Baseline (T0)4
Differences in Baseline SII Between Good and Poor Responders
Comparison of baseline systemic immune-inflammation index between good and poor responders in the periodontitis group.
Time frame
Baseline (T0)Locations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Erzincan Binali Yıldırım University Faculty of DentistryRecruiting24002, Merkez, ErzincanTurkey (Türkiye)
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Ömer Faruk Okumuş
Lead sponsor
Erzincan University
Sponsor institution
Erzincan Binali Yildirim Universitesi
Collaborator
Source ClinicalTrials.gov