Handgrip Training and Brain Blood Flow Regulation
ConditionInactivity/Low Levels of Exercise
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorFlorida State University
About this trial
This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18 to 35 years old
Body mass index ≤30 kg/m2 (without obesity)
Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months
Have a smartphone and are willing to download mobile applications used in this project
Disqualifiers
Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)
Being pregnant, planning to become pregnant, or breastfeeding/lactating
Regular use of nicotine products in the past 6 months
Recent head injury/trauma or concussion
Trial design
Design model
Parallel
Treatments tested in this trial
Handgrip Training
DeviceHandgrip training 3 days per week for 8 weeks
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: Isometric Handgrip Training - InterventionExperimental treatment 1 intervention
Group B: Isometric Handgrip Training - ShamSham comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in middle cerebral artery blood velocity reactivity to hypercapnia
Middle cerebral artery blood velocity will be measured via transcranial Doppler ultrasound
Time frame
Up to 9 weeksSecondary outcomes
1
Change in middle cerebral artery blood velocity reactivity to hypocapnia
Middle cerebral artery blood velocity will be measured via transcranial Doppler ultrasound
Time frame
Up to 9 weeks2
Brachial systolic blood pressure
Blood pressure measured at the brachial artery
Time frame
Up to 9 weeks3
Change in dynamic cerebral autoregulation phase
Calculated from middle cerebral artery blood velocity signal using transfer function analysis
Time frame
Up to 9 weeks4
Change in dynamic cerebral autoregulation gain
Calculated from middle cerebral artery blood velocity signal using transfer function analysis
Time frame
Up to 9 weeksSponsors and contacts
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Source ClinicalTrials.gov