Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-40
SponsorUniversity of British Columbia
About this trial
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 19-40
Healthy, with no history of respiratory disease
Lifetime non-smoker and non-vaper.
Disqualifiers
Pregnant, planning to become pregnant, or breastfeeding during the study period (confirmed through pregnancy tests at each visit if applicable)
Frequent WS or DE exposures (e.g. home fireplace used for heating/cooking, or employment in transportation, mining, or as a firefighter).
Trial design
Design model
Crossover
Treatments tested in this trial
Filtered Air (FA)
Other interventionExposure to HEPA filtered air, as a control
Wood Smoke (WS)
Other interventionWood smoke (WS) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Diesel Exhaust (DE)
Other interventionDiesel exhaust (DE) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Diesel Exhaust and Wood Smoke (DEWS)
Other interventionCombined diesel exhaust and wood smoke standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Treatment groups
48 Participants
are divided into 4 treatment groupsGroup A: Filtered Air (FA)Placebo comparator 1 intervention
Group B: Wood Smoke (WS)Active comparator 1 intervention
Group C: Diesel Exhaust (DE)Active comparator 1 intervention
Group D: Diesel Exhaust and Wood Smoke (DEWS)Active comparator 1 intervention
Trial outcomes
Primary outcomes
1
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the lungs.
Differentially count lung cells.
Time frame
Comparison of the different arms (over the span of ~5 months).2
Within-individual change in lung transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in lung biomarkers of inflammation (serum amyloid A (SAA), c-reactive protein (CRP), chemokine ligand 18 (CCL18), and fibrinogen) in RNA.
Time frame
Through study completion, anticipated ~5 months.3
Within-individual change in lung protein biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in lung biomarkers of inflammation (serum amyloid A (SAA), c-reactive protein (CRP), chemokine ligand 18 (CCL18), and fibrinogen) in protein.
Time frame
Through study completion, anticipated ~5 months.4
Within-individual change in circulating transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in circulating biomarkers of inflammation (CX3CL1, CCL23, CXCL8, SAA, MMP9, MMP12, APOB, APOM, SOD1, NQO1, HMOX1, CAT, CYP1B1, CYP1A2, NFE2L2 and AHRR) in RNA.
Time frame
Through study completion, anticipated ~5 months.Secondary outcomes
1
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the nose.
Differentially count nasal cells.
Time frame
Comparison of the different arms (over the span of ~5 months).2
Within-individual changes in exhaled nitric oxide following woodsmoke (WS) and/or diesel exhaust (DE) exposures.
Measurement of fractional exhaled nitric oxide (FeNO) in parts per billion (ppb).
Time frame
Comparison of the different arms (over the span of ~5 months).3
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on symptoms, stress and perceptions.
Visual analog score (0-100) questionnaire will be completed, with a higher score indicating a worse outcome.
Time frame
Comparison of the different arms (over the span of ~5 months).4
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on lung function.
Lung function as evaluated by spirometry (e.g. FEV1).
Time frame
Comparison of the different arms (over the span of ~5 months).Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: