Chronic liver disease (CLD) in children can sometimes lead to complications in other parts of the body, including the heart. The primary purpose of this observational study is to assess the presence and type of cardiac problems in children who have been diagnosed with chronic liver disease.
Researchers will observe children under the age of 18 who are receiving care at the gastroenterology and hepatology unit at Assiut University Children Hospital. Participants will undergo standard medical evaluations to check both their liver and heart health.
These evaluations include:
* A detailed medical history and thorough physical examination * Routine blood tests to check liver function, kidney function, coagulation, and electrolytes * Abdominal imaging, such as an ultrasound, to look at the liver. * An electrocardiogram (ECG) to check the heart's electrical activity and rhythm, including measuring the QTc interval. * An echocardiogram to look at the structure of the heart and check how well its chambers and valves are functioning.
The study aims to identify specific heart conditions that can be associated with severe liver disease, such as portopulmonary hypertension, cirrhotic cardiomyopathy (changes in the heart muscle's function), and electrical repolarization abnormalities. Children who already have known congenital heart disease or a history of other heart problems will not be included in the study.
All patients below 18 years who diagnosed with chronic liver disease.
All patients known to have congenital heart disease or previous cardiac disease.
The study population will consist of pediatric patients (under 18 years of age) diagnosed with chronic liver disease who are attending the gastroenterology and hepatology unit at Assiut University Children's Hospital. The population will include patients with various underlying causes of chronic liver disease, such as autoimmune hepatitis, viral hepatitis (B and C), Wilson's disease, and cystic fibrosis. Patients with known congenital heart disease or a history of previous cardiac disease will be excluded from this population.
Cohort
Prospective
Not listed
Corrected QT (QTc) Interval
The corrected QT (QTc) interval will be measured using an electrocardiogram (ECG) to evaluate for cardiac repolarization abnormalities.
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