Hematological Profile in Children With Numerical Chromosomal Disorders
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age28-18
SponsorAssiut University
About this trial
This cross-sectional study aims to evaluate the hematological profile and determine the frequency and pattern of hematological abnormalities in children with numerical chromosomal disorders attending the Pediatric Department of Assiut University Children's Hospital.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
- Age from 28 days to 18 years
Confirmed numerical chromosomal disorder (Down syndrome, Turner syndrome, Klinefelter syndrome, Edwards syndrome, or Patau syndrome) by karyotype
Written informed consent from parents or legal guardians
Disqualifiers
- Age below 28 days
Patients receiving chemotherapy
Refusal of parents or legal guardians to participate
Trial population
Children aged 28 days to 18 years diagnosed with numerical chromosomal disorders attending the Pediatric Department of Assiut University Children's Hospital.
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
158 Participants
are grouped into 1 trial groupGroup A: Single cohort: Children with numerical chromosomal disorders
Trial outcomes
Primary outcomes
1
Frequency of hematological abnormalities
Proportion of children with numerical chromosomal disorders who have one or more hematological abnormalities (anemia, macrocytosis, thrombocytopenia, leukopenia, leukocytosis, or abnormal peripheral blood smear findings), expressed as percentage.
Time frame
BaselineSecondary outcomes
1
Pattern of hematological abnormalities
Distribution and pattern of specific hematological abnormalities (anemia, macrocytosis, thrombocytopenia, neutropenia, etc.) among the studied children.
Time frame
Baseline2
Hematological profile according to syndrome type
Comparison of hematological parameters (hemoglobin, MCV, platelet count, white blood cell count) among different numerical chromosomal disorders (Down syndrome, Turner syndrome, and others).
Time frame
Baseline3
Correlation of hematological abnormalities with clinical features
Correlation coefficient between the presence of hematological abnormalities and clinical features (recurrent infections, bleeding manifestations, hepatosplenomegaly), using Spearman or Pearson correlation as appropriate.
Time frame
BaselineLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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